Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054172009> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2054172009 endingPage "56" @default.
- W2054172009 startingPage "50" @default.
- W2054172009 abstract "Summary: Pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone (TRH), and metoclopramide (MC) was studied in 40 epileptic patients (24 men and 16 women) receiving carbamazepine (CBZ) treatment and in 29 (20 men and 9 women) untreated epileptic patients. Mean basal concentration of serum LH was significantly lower in the CBZ-treated female patients than in untreated female patients. The response of LH to LH-RH was also blunted in CBZ-treated female patients. No differences were found in basal or stimulated LH levels between the two groups of male patients. Nevertheless, the mean basal concentration of serum prolactin (PRL) was lower and the response of PRL to TRH was higher in male patients treated with CBZ. No differences were found in serum levels of follicle-stimulating hormone (FSH) or in responses of FSH to LH-RH between the CBZ-treated and untreated patients. These results indicate that CBZ has effects on pituitary responsiveness. RÉSUMÉ La réponse pituitaire à la LHRH, à la TRH et au métoclopramide (MC) a étét́udié chez 40 patients épileptiques (24 M, 16 F) traités par CBZ et chez 29 patients épileptiques (20 M, 9 F) non traités. Les taux sanguins de base de LH étaient significa-tivement plus bas chez les sujets féminins traites que non traités. La réponse au LHRH était également émousseé chez les femmés traitees. II n'a pas été constaté de différence des LH de base ou post-stimulatives entre patients másculins traités ou non traités. La concentration basale moyenne de prolactine (PRL) était cependant plus basse et la réponse de la PRL sous TRH plus élevée chez les sujets másculins traités par CBZ. II n'a pas été trouvé de différence des taux sanguins de FSH de base ou après LHRH entre les patients traités et les patients non traités. Ces résultats montrent que la CBZ a des effets sur la réactivité hypophysaire. RESUMEN En 40 enfermos epilépticos (24 varones y 16 hembras), recibiendo un tratamiento con carbamazepine (CBZ), y en 29 enfermos epilépticos (20 varones y 9 hembras) no tratados, se nan estudi-ado las respuestas de la hipófisis a la hormona liberadora de la hormona luteinizante (LH-RH), a la hormona liberadora de tiro-tropina (TR) y a la metoclopramida (MH). Las concentraciones basales medias en suero de la LH fueron significativamente más bajas en las hembras tratadas con CBZ que en las hembras no tratadas. Las respuestas de la LH a la LH-RH apareció tam-bien atenuada en las enfermás tratadas con CBZ. No se encon-traron diferencias en los niveles basales o estimulados por la LH, entre los dos grupos de enfermos varones. Sin embargo las concentraciones séricas medias basales de prolactina (PRL) fueron más bajas y las respuestas de la PRL a la TRH fue más elevada en los pacientes varones tratados con CBZ. No se encontraron diferencias en los niveles séricos de la hormona estimulante folicular (FSH) o en las respuestas de la FSH a la LH-RH entre los pacientes tratados con CBZ o los no tratados. Estos resultados indican que la CBZ produce efectos sobre las respuestas de la hipófisis. ZUSAMMENFASSUNG Bei 40 Epileptikern (24 männlich, 16 weiblich) unter Carba-mazepin-Behandlung und bei 29 unbehandelten Epileptikern (20 mannlich, 9 weiblich) wurde die Hypophysenreaktion auf das LH-RH-System, auf TRH und auf Metoclopramid (MC) unter-sucht. Die mittleren basalen Konzentrationen von Serum-LH waren signifikant geringer bei den behandelten weiblichen als bei unbehandelten weiblichen Patienten. Die LH-Antwort auf LH-RH war ebenfalls unter Carbamazepin abgeschwächt. Bei den beiden mannlichen Patientengruppen konnten keine Unter-schiede in den basalen oder stimuherten LH-Spiegeln gefunden werden. Dennoch waren bei den männlichen Patienten unter Carbamazepin die mittleren basalen Konzetrationen von Serum-Prolactin (PRL) geringer und die Antwort von PRL auf TRH hoher. Bei den Serum-spiegeln des FSH und in der Antwort von FSH auf LH-RH waren keine Unterschiede zwischen den Car-bamazepin-behandelten und-nicht-behandelten Patienten zu fin-den. Die Ergebnisse zeigen einen Einfluß von Carbamazepine auf die Hypophysenansprechbarkeit." @default.
- W2054172009 created "2016-06-24" @default.
- W2054172009 creator A5005022085 @default.
- W2054172009 creator A5013863914 @default.
- W2054172009 creator A5060176494 @default.
- W2054172009 date "1989-02-01" @default.
- W2054172009 modified "2023-09-27" @default.
- W2054172009 title "Effects of Carbamazepine on Pituitary Responsiveness to Luteinizing Hormone-Releasing Hormone, Thyrotropin-Releasing Hormone, and Metoclopramide in Epileptic Patients" @default.
- W2054172009 cites W1890987751 @default.
- W2054172009 cites W1975599180 @default.
- W2054172009 cites W1988297715 @default.
- W2054172009 cites W2033523404 @default.
- W2054172009 cites W2040741797 @default.
- W2054172009 cites W2046461268 @default.
- W2054172009 cites W2067626725 @default.
- W2054172009 cites W2078508640 @default.
- W2054172009 cites W2092706688 @default.
- W2054172009 cites W2103251643 @default.
- W2054172009 cites W2107611564 @default.
- W2054172009 cites W2125147801 @default.
- W2054172009 cites W2222477488 @default.
- W2054172009 cites W4236676256 @default.
- W2054172009 cites W4251533758 @default.
- W2054172009 doi "https://doi.org/10.1111/j.1528-1157.1989.tb05280.x" @default.
- W2054172009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2492224" @default.
- W2054172009 hasPublicationYear "1989" @default.
- W2054172009 type Work @default.
- W2054172009 sameAs 2054172009 @default.
- W2054172009 citedByCount "31" @default.
- W2054172009 countsByYear W20541720092012 @default.
- W2054172009 countsByYear W20541720092015 @default.
- W2054172009 countsByYear W20541720092022 @default.
- W2054172009 crossrefType "journal-article" @default.
- W2054172009 hasAuthorship W2054172009A5005022085 @default.
- W2054172009 hasAuthorship W2054172009A5013863914 @default.
- W2054172009 hasAuthorship W2054172009A5060176494 @default.
- W2054172009 hasConcept C118552586 @default.
- W2054172009 hasConcept C126322002 @default.
- W2054172009 hasConcept C134018914 @default.
- W2054172009 hasConcept C2776216936 @default.
- W2054172009 hasConcept C2778024521 @default.
- W2054172009 hasConcept C2778186239 @default.
- W2054172009 hasConcept C2778479196 @default.
- W2054172009 hasConcept C2778575703 @default.
- W2054172009 hasConcept C2779064019 @default.
- W2054172009 hasConcept C2779253243 @default.
- W2054172009 hasConcept C2779279165 @default.
- W2054172009 hasConcept C2779306644 @default.
- W2054172009 hasConcept C2780852908 @default.
- W2054172009 hasConcept C71315377 @default.
- W2054172009 hasConcept C71924100 @default.
- W2054172009 hasConceptScore W2054172009C118552586 @default.
- W2054172009 hasConceptScore W2054172009C126322002 @default.
- W2054172009 hasConceptScore W2054172009C134018914 @default.
- W2054172009 hasConceptScore W2054172009C2776216936 @default.
- W2054172009 hasConceptScore W2054172009C2778024521 @default.
- W2054172009 hasConceptScore W2054172009C2778186239 @default.
- W2054172009 hasConceptScore W2054172009C2778479196 @default.
- W2054172009 hasConceptScore W2054172009C2778575703 @default.
- W2054172009 hasConceptScore W2054172009C2779064019 @default.
- W2054172009 hasConceptScore W2054172009C2779253243 @default.
- W2054172009 hasConceptScore W2054172009C2779279165 @default.
- W2054172009 hasConceptScore W2054172009C2779306644 @default.
- W2054172009 hasConceptScore W2054172009C2780852908 @default.
- W2054172009 hasConceptScore W2054172009C71315377 @default.
- W2054172009 hasConceptScore W2054172009C71924100 @default.
- W2054172009 hasIssue "1" @default.
- W2054172009 hasLocation W20541720091 @default.
- W2054172009 hasLocation W20541720092 @default.
- W2054172009 hasOpenAccess W2054172009 @default.
- W2054172009 hasPrimaryLocation W20541720091 @default.
- W2054172009 hasRelatedWork W1989172094 @default.
- W2054172009 hasRelatedWork W1994104316 @default.
- W2054172009 hasRelatedWork W2036239614 @default.
- W2054172009 hasRelatedWork W2037761748 @default.
- W2054172009 hasRelatedWork W2038753834 @default.
- W2054172009 hasRelatedWork W2077925316 @default.
- W2054172009 hasRelatedWork W2089937133 @default.
- W2054172009 hasRelatedWork W2091556654 @default.
- W2054172009 hasRelatedWork W2095933318 @default.
- W2054172009 hasRelatedWork W2150096959 @default.
- W2054172009 hasVolume "30" @default.
- W2054172009 isParatext "false" @default.
- W2054172009 isRetracted "false" @default.
- W2054172009 magId "2054172009" @default.
- W2054172009 workType "article" @default.