FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054173689> ?p ?o ?g. }

• W2054173689 endingPage "510" @default.
• W2054173689 startingPage "500" @default.
• W2054173689 abstract "Controversy exists over whether the lower airway inflammation that characterizes cystic fibrosis (CF) is initiated primarily by the genetic defect. To determine if inflammation precedes infection, we examined bronchoalveolar lavage (BAL) fluid cytology, cytokines (interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor-α), and free neutrophil elastase activity from 70 CF (aged 1.5–71 months) children detected by newborn screening and 19 (aged 2.0–48 months) controls with chronic stridor. CF subjects were selected and categorized as pristine (13 aged ≤ 6 months, lacking prior respiratory symptoms and exposure to antibiotics, and without respiratory pathogens on BAL), infected (42 with viruses or ≥ 105 colony-forming units/ml of pathogenic bacteria in BAL), and uninfected (15 aged > 6 months, asymptomatic, not taking antibiotics at bronchoscopy, and free of pathogens in their BAL). To further resolve if inflammation develops without infection, inflammatory mediators in paired annual BAL samples from 38 CF subjects were measured, and results were grouped according to whether BAL showed persistence (n = 6), acquisition (n = 8), clearance (n = 13), or absence (n = 11) of infection. While pristine, uninfected, and control subjects had similar BAL profiles, infected patients showed elevated inflammatory indices, including increased IL-10 (P < 0.001). Pristine subjects had the fewest signs of inflammation. Analysis of BAL pairs found differences between the four infection groups for changes in neutrophil percentages, IL-8 (P < 0.001), and free neutrophil elastase (P = 0.009). Infection was associated with elevated inflammatory mediators in BAL fluid. In contrast, minimal or reduced signs of inflammation accompanied absence of eradication of infection from BAL fluid. We conclude that in CF, infection initiates and sustains airway inflammation. Pediatr Pulmonol. © 2005 Wiley-Liss, Inc." @default.
• W2054173689 created "2016-06-24" @default.
• W2054173689 creator A5022130886 @default.
• W2054173689 creator A5030122881 @default.
• W2054173689 creator A5032236372 @default.
• W2054173689 creator A5038509173 @default.
• W2054173689 creator A5048071579 @default.
• W2054173689 creator A5075778865 @default.
• W2054173689 creator A5078528997 @default.
• W2054173689 creator A5087490703 @default.
• W2054173689 date "2005-01-01" @default.
• W2054173689 modified "2023-09-23" @default.
• W2054173689 title "Lower Airway Inflammation in Infants with Cystic Fibrosis Detected by Newborn Screening" @default.
• W2054173689 cites W118353332 @default.
• W2054173689 cites W1967279039 @default.
• W2054173689 cites W1975959231 @default.
• W2054173689 cites W1980017808 @default.
• W2054173689 cites W1989694167 @default.
• W2054173689 cites W1990758067 @default.
• W2054173689 cites W1998195903 @default.
• W2054173689 cites W2003654071 @default.
• W2054173689 cites W2013340198 @default.
• W2054173689 cites W2019467489 @default.
• W2054173689 cites W2028223319 @default.
• W2054173689 cites W2038033588 @default.
• W2054173689 cites W2055101660 @default.
• W2054173689 cites W2056291443 @default.
• W2054173689 cites W2057061730 @default.
• W2054173689 cites W2057496127 @default.
• W2054173689 cites W2058107166 @default.
• W2054173689 cites W2060296327 @default.
• W2054173689 cites W2064017727 @default.
• W2054173689 cites W2066484939 @default.
• W2054173689 cites W2076054450 @default.
• W2054173689 cites W2081941108 @default.
• W2054173689 cites W2088849723 @default.
• W2054173689 cites W2089050279 @default.
• W2054173689 cites W2096909137 @default.
• W2054173689 cites W2099058418 @default.
• W2054173689 cites W2102684777 @default.
• W2054173689 cites W2107884278 @default.
• W2054173689 cites W2113453073 @default.
• W2054173689 cites W2123151875 @default.
• W2054173689 cites W2124628678 @default.
• W2054173689 cites W2127386964 @default.
• W2054173689 cites W2128205630 @default.
• W2054173689 cites W2128547781 @default.
• W2054173689 cites W2137563519 @default.
• W2054173689 cites W2137905555 @default.
• W2054173689 cites W2138384547 @default.
• W2054173689 cites W2140036922 @default.
• W2054173689 cites W2144073321 @default.
• W2054173689 cites W2157840344 @default.
• W2054173689 cites W2158024739 @default.
• W2054173689 cites W2165164647 @default.
• W2054173689 cites W2171864472 @default.
• W2054173689 cites W2468227652 @default.
• W2054173689 doi "https://doi.org/10.1002/ppul.20294" @default.
• W2054173689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16208679" @default.
• W2054173689 hasPublicationYear "2005" @default.
• W2054173689 type Work @default.
• W2054173689 sameAs 2054173689 @default.
• W2054173689 citedByCount "210" @default.
• W2054173689 countsByYear W20541736892012 @default.
• W2054173689 countsByYear W20541736892013 @default.
• W2054173689 countsByYear W20541736892014 @default.
• W2054173689 countsByYear W20541736892015 @default.
• W2054173689 countsByYear W20541736892016 @default.
• W2054173689 countsByYear W20541736892017 @default.
• W2054173689 countsByYear W20541736892018 @default.
• W2054173689 countsByYear W20541736892019 @default.
• W2054173689 countsByYear W20541736892020 @default.
• W2054173689 countsByYear W20541736892021 @default.
• W2054173689 countsByYear W20541736892022 @default.
• W2054173689 countsByYear W20541736892023 @default.
• W2054173689 crossrefType "journal-article" @default.
• W2054173689 hasAuthorship W2054173689A5022130886 @default.
• W2054173689 hasAuthorship W2054173689A5030122881 @default.
• W2054173689 hasAuthorship W2054173689A5032236372 @default.
• W2054173689 hasAuthorship W2054173689A5038509173 @default.
• W2054173689 hasAuthorship W2054173689A5048071579 @default.
• W2054173689 hasAuthorship W2054173689A5075778865 @default.
• W2054173689 hasAuthorship W2054173689A5078528997 @default.
• W2054173689 hasAuthorship W2054173689A5087490703 @default.
• W2054173689 hasConcept C126322002 @default.
• W2054173689 hasConcept C142724271 @default.
• W2054173689 hasConcept C17991360 @default.
• W2054173689 hasConcept C181199279 @default.
• W2054173689 hasConcept C203014093 @default.
• W2054173689 hasConcept C2776178081 @default.
• W2054173689 hasConcept C2776317360 @default.
• W2054173689 hasConcept C2776914184 @default.
• W2054173689 hasConcept C2776938444 @default.
• W2054173689 hasConcept C2777714996 @default.
• W2054173689 hasConcept C2777910003 @default.
• W2054173689 hasConcept C2777961210 @default.
• W2054173689 hasConcept C2781044401 @default.
• W2054173689 hasConcept C55493867 @default.

• next