FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054177581> ?p ?o ?g. }

• W2054177581 endingPage "8052" @default.
• W2054177581 startingPage "8040" @default.
• W2054177581 abstract "Reduced activity of the mitochondrial respiratory chain and in particular of complex I is implicated not only in the etiology of Parkinson's disease but also in other forms of parkinsonism in which striatal neurodegeneration occurs, such as progressive supranuclear palsy. The pesticide rotenone inhibits mitochondrial complex I and reproduces features of these basal ganglia neurological disorders in animal models. We have characterized the electrophysiological effects of rotenone in the striatum as well as potential neuroprotective strategies to counteract the detrimental effects of this neurotoxin. We found that rotenone causes a dose-dependent and irreversible loss of the corticostriatal field potential amplitude, which was related to the development of a membrane depolarization/inward current in striatal spiny neurons, coupled to an increased release of both excitatory amino acids and dopamine (DA). In particular, we have investigated whether glutamate, DA, and GABA systems might represent possible targets for neuroprotection against rotenone-induced striatal neuronal dysfunction. Interestingly, whereas modulation of glutamatergic transmission was not neuroprotective, blockade of D(2)-like but not D(1)-like DA receptors significantly reduced the rotenone-induced effects via a GABA-mediated mechanism. In addition, because antiepileptic drugs (AEDs) modulate multiple transmitter systems, we have analyzed the possible neuroprotective effects of some AEDs against rotenone. We found that carbamazepine, unlike other tested AEDs, exerts a potent neuroprotective action against rotenone-induced striatal neuronal dysfunction. This neuroprotection was observed at therapeutically relevant concentrations requiring endogenous GABA. Differential targeting of GABAergic transmission may represent a possible therapeutic strategy against basal ganglia neurodegenerative disorders involving mitochondrial complex I dysfunction." @default.
• W2054177581 created "2016-06-24" @default.
• W2054177581 creator A5003176709 @default.
• W2054177581 creator A5015556586 @default.
• W2054177581 creator A5016771131 @default.
• W2054177581 creator A5020091962 @default.
• W2054177581 creator A5035870058 @default.
• W2054177581 creator A5037065292 @default.
• W2054177581 creator A5037609259 @default.
• W2054177581 creator A5050850872 @default.
• W2054177581 creator A5058349842 @default.
• W2054177581 creator A5068550013 @default.
• W2054177581 creator A5081582944 @default.
• W2054177581 creator A5088823694 @default.
• W2054177581 creator A5089797464 @default.
• W2054177581 date "2008-08-06" @default.
• W2054177581 modified "2023-10-11" @default.
• W2054177581 title "Electrophysiology and Pharmacology of Striatal Neuronal Dysfunction Induced by Mitochondrial Complex I Inhibition" @default.
• W2054177581 cites W104349838 @default.
• W2054177581 cites W1504584187 @default.
• W2054177581 cites W1584829548 @default.
• W2054177581 cites W1624116415 @default.
• W2054177581 cites W1893053185 @default.
• W2054177581 cites W1930159471 @default.
• W2054177581 cites W1938199221 @default.
• W2054177581 cites W1954514489 @default.
• W2054177581 cites W1966443363 @default.
• W2054177581 cites W1971389338 @default.
• W2054177581 cites W1979786105 @default.
• W2054177581 cites W1985952197 @default.
• W2054177581 cites W1987398739 @default.
• W2054177581 cites W1990402607 @default.
• W2054177581 cites W1991780447 @default.
• W2054177581 cites W1998238272 @default.
• W2054177581 cites W1999892645 @default.
• W2054177581 cites W2001771542 @default.
• W2054177581 cites W2007327549 @default.
• W2054177581 cites W2010268515 @default.
• W2054177581 cites W2012971273 @default.
• W2054177581 cites W2017083493 @default.
• W2054177581 cites W2018811378 @default.
• W2054177581 cites W2022171870 @default.
• W2054177581 cites W2025239936 @default.
• W2054177581 cites W2027319274 @default.
• W2054177581 cites W2028167712 @default.
• W2054177581 cites W2030747609 @default.
• W2054177581 cites W2030785267 @default.
• W2054177581 cites W2032421019 @default.
• W2054177581 cites W2035639156 @default.
• W2054177581 cites W2042717783 @default.
• W2054177581 cites W2044492675 @default.
• W2054177581 cites W2045698094 @default.
• W2054177581 cites W2055308573 @default.
• W2054177581 cites W2057250794 @default.
• W2054177581 cites W2058077554 @default.
• W2054177581 cites W2065214055 @default.
• W2054177581 cites W2069844783 @default.
• W2054177581 cites W2073351779 @default.
• W2054177581 cites W2081355012 @default.
• W2054177581 cites W2081819423 @default.
• W2054177581 cites W2082194278 @default.
• W2054177581 cites W2093093973 @default.
• W2054177581 cites W2098789626 @default.
• W2054177581 cites W2111740724 @default.
• W2054177581 cites W2115520041 @default.
• W2054177581 cites W2121229721 @default.
• W2054177581 cites W2124405216 @default.
• W2054177581 cites W2148237460 @default.
• W2054177581 cites W2152985670 @default.
• W2054177581 cites W4322388886 @default.
• W2054177581 doi "https://doi.org/10.1523/jneurosci.1947-08.2008" @default.
• W2054177581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6670775" @default.
• W2054177581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18685029" @default.
• W2054177581 hasPublicationYear "2008" @default.
• W2054177581 type Work @default.
• W2054177581 sameAs 2054177581 @default.
• W2054177581 citedByCount "54" @default.
• W2054177581 countsByYear W20541775812012 @default.
• W2054177581 countsByYear W20541775812013 @default.
• W2054177581 countsByYear W20541775812014 @default.
• W2054177581 countsByYear W20541775812015 @default.
• W2054177581 countsByYear W20541775812016 @default.
• W2054177581 countsByYear W20541775812017 @default.
• W2054177581 countsByYear W20541775812018 @default.
• W2054177581 countsByYear W20541775812019 @default.
• W2054177581 countsByYear W20541775812020 @default.
• W2054177581 countsByYear W20541775812021 @default.
• W2054177581 countsByYear W20541775812022 @default.
• W2054177581 countsByYear W20541775812023 @default.
• W2054177581 crossrefType "journal-article" @default.
• W2054177581 hasAuthorship W2054177581A5003176709 @default.
• W2054177581 hasAuthorship W2054177581A5015556586 @default.
• W2054177581 hasAuthorship W2054177581A5016771131 @default.
• W2054177581 hasAuthorship W2054177581A5020091962 @default.
• W2054177581 hasAuthorship W2054177581A5035870058 @default.
• W2054177581 hasAuthorship W2054177581A5037065292 @default.
• W2054177581 hasAuthorship W2054177581A5037609259 @default.
• W2054177581 hasAuthorship W2054177581A5050850872 @default.

• next