FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054178918> ?p ?o ?g. }

• W2054178918 endingPage "26" @default.
• W2054178918 startingPage "21" @default.
• W2054178918 abstract "The present study was designed to clarify the mechanism of nickel (Ni) uptake in primary cultures of rat hepatocytes. Exposure of the hepatocytes to Ni (2–50 μM; as NiCl2) for up to 6 h was not cytotoxic, as assessed by the tetrazolium-based dye (MTT) assay. Hepatocytes were treated with 10 μM NiCl2 in the absence or presence of calcium (Ca) and magnesium (Mg) (1 mM). Ni uptake was increased by 19% in medium lacking Mg or Ca and was increased by 37% in Ca- and Mg-free medium. The role of Ca channels on Ni uptake by the hepatocytes was investigated. Pretreatment with nicardipine or verapamil (200 μM), potent inhibitors of Ca channels, decreased Ni uptake by 20%. This effect was only observed when the cells were incubated in the absence of Ca. Pretreatment with vasopressin (100 nM), a well-known Ca channel agonist, significantly increased Ni uptake by the hepatocytes (24%). To determine the involvement of carrier-mediated processes on Ni uptake, the effect of temperature was also investigated. At 4°C the Ni uptake was decreased by 20% compared to uptake at 37°C. These results indicate that Ni uptake by the hepatocytes occurs, at least in part, through the Ca channel transport processes. Further study will be required to assess what other mechanisms are involved." @default.
• W2054178918 created "2016-06-24" @default.
• W2054178918 creator A5025224510 @default.
• W2054178918 creator A5032870217 @default.
• W2054178918 creator A5043590671 @default.
• W2054178918 creator A5053679405 @default.
• W2054178918 date "1997-12-19" @default.
• W2054178918 modified "2023-09-23" @default.
• W2054178918 title "The mechanisms of nickel uptake by rat primary hepatocyte cultures: role of calcium channels" @default.
• W2054178918 cites W1548545916 @default.
• W2054178918 cites W1938690075 @default.
• W2054178918 cites W1968381948 @default.
• W2054178918 cites W1973461290 @default.
• W2054178918 cites W1982006437 @default.
• W2054178918 cites W1985715879 @default.
• W2054178918 cites W2004513791 @default.
• W2054178918 cites W2017123110 @default.
• W2054178918 cites W2032800107 @default.
• W2054178918 cites W2040596374 @default.
• W2054178918 cites W2042217106 @default.
• W2054178918 cites W2054771247 @default.
• W2054178918 cites W2056243299 @default.
• W2054178918 cites W2072482644 @default.
• W2054178918 cites W2091202236 @default.
• W2054178918 cites W210146383 @default.
• W2054178918 cites W2114918609 @default.
• W2054178918 cites W2116543832 @default.
• W2054178918 cites W2141954222 @default.
• W2054178918 cites W2255254656 @default.
• W2054178918 cites W2271403741 @default.
• W2054178918 cites W2332171092 @default.
• W2054178918 cites W2336296801 @default.
• W2054178918 cites W2414676731 @default.
• W2054178918 cites W2419107425 @default.
• W2054178918 cites W292191046 @default.
• W2054178918 cites W643792371 @default.
• W2054178918 doi "https://doi.org/10.1016/s0300-483x(97)00131-5" @default.
• W2054178918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9392452" @default.
• W2054178918 hasPublicationYear "1997" @default.
• W2054178918 type Work @default.
• W2054178918 sameAs 2054178918 @default.
• W2054178918 citedByCount "33" @default.
• W2054178918 countsByYear W20541789182012 @default.
• W2054178918 countsByYear W20541789182013 @default.
• W2054178918 countsByYear W20541789182015 @default.
• W2054178918 countsByYear W20541789182016 @default.
• W2054178918 countsByYear W20541789182017 @default.
• W2054178918 countsByYear W20541789182020 @default.
• W2054178918 countsByYear W20541789182021 @default.
• W2054178918 countsByYear W20541789182022 @default.
• W2054178918 crossrefType "journal-article" @default.
• W2054178918 hasAuthorship W2054178918A5025224510 @default.
• W2054178918 hasAuthorship W2054178918A5032870217 @default.
• W2054178918 hasAuthorship W2054178918A5043590671 @default.
• W2054178918 hasAuthorship W2054178918A5053679405 @default.
• W2054178918 hasConcept C12554922 @default.
• W2054178918 hasConcept C134018914 @default.
• W2054178918 hasConcept C178790620 @default.
• W2054178918 hasConcept C185592680 @default.
• W2054178918 hasConcept C18699975 @default.
• W2054178918 hasConcept C202751555 @default.
• W2054178918 hasConcept C2776200302 @default.
• W2054178918 hasConcept C2777022698 @default.
• W2054178918 hasConcept C2778043224 @default.
• W2054178918 hasConcept C41625074 @default.
• W2054178918 hasConcept C519063684 @default.
• W2054178918 hasConcept C55493867 @default.
• W2054178918 hasConcept C85520022 @default.
• W2054178918 hasConcept C86803240 @default.
• W2054178918 hasConcept C98274493 @default.
• W2054178918 hasConcept C99975950 @default.
• W2054178918 hasConceptScore W2054178918C12554922 @default.
• W2054178918 hasConceptScore W2054178918C134018914 @default.
• W2054178918 hasConceptScore W2054178918C178790620 @default.
• W2054178918 hasConceptScore W2054178918C185592680 @default.
• W2054178918 hasConceptScore W2054178918C18699975 @default.
• W2054178918 hasConceptScore W2054178918C202751555 @default.
• W2054178918 hasConceptScore W2054178918C2776200302 @default.
• W2054178918 hasConceptScore W2054178918C2777022698 @default.
• W2054178918 hasConceptScore W2054178918C2778043224 @default.
• W2054178918 hasConceptScore W2054178918C41625074 @default.
• W2054178918 hasConceptScore W2054178918C519063684 @default.
• W2054178918 hasConceptScore W2054178918C55493867 @default.
• W2054178918 hasConceptScore W2054178918C85520022 @default.
• W2054178918 hasConceptScore W2054178918C86803240 @default.
• W2054178918 hasConceptScore W2054178918C98274493 @default.
• W2054178918 hasConceptScore W2054178918C99975950 @default.
• W2054178918 hasIssue "1" @default.
• W2054178918 hasLocation W20541789181 @default.
• W2054178918 hasLocation W20541789182 @default.
• W2054178918 hasOpenAccess W2054178918 @default.
• W2054178918 hasPrimaryLocation W20541789181 @default.
• W2054178918 hasRelatedWork W1970661282 @default.
• W2054178918 hasRelatedWork W1988303587 @default.
• W2054178918 hasRelatedWork W2007160026 @default.
• W2054178918 hasRelatedWork W2020275754 @default.
• W2054178918 hasRelatedWork W2038400812 @default.
• W2054178918 hasRelatedWork W2054178918 @default.

• next