FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054194478> ?p ?o ?g. }

• W2054194478 endingPage "1137" @default.
• W2054194478 startingPage "1128" @default.
• W2054194478 abstract "The cell-surface expression of GM1 ganglioside was studied using various cultured cells, including brain-derived endothelial cells, astrocytes, neuroblastoma cells (SH-SY5Y), and pheochromocytoma cells (PC12). GM1 ganglioside was detected only on the surface of native and nerve-growth-factor (NGF)-treated PC12 cells. We investigated whether GM1 ganglioside on the surface of these cells is sufficiently potent to induce the assembly of an exogenous soluble amyloid beta-protein (Abeta). A marked Abeta assembly was observed in the culture of NGF-treated PC12 cells. Notably, immunocytochemical study revealed that, despite the ubiquitous surface expression of GM1 ganglioside throughout cell bodies and neurites, Abeta assembly initially occurred at the terminals of SNAP25-immunopositive neurites. Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta). In primary neuronal cultures, Abeta assembly initially occurred at synaptophysin-positive sites. These results suggest that the cell-surface expression of GM1 ganglioside is strictly cell-type-specific, and that expression of GM1 ganglioside on synaptic membranes is unique in terms of its high potency to induce Abeta assembly through the generation of GAbeta, which is an endogenous seed for Abeta assembly in Alzheimer brain." @default.
• W2054194478 created "2016-06-24" @default.
• W2054194478 creator A5010466289 @default.
• W2054194478 creator A5022355683 @default.
• W2054194478 creator A5049284705 @default.
• W2054194478 creator A5058071088 @default.
• W2054194478 date "2007-05-01" @default.
• W2054194478 modified "2023-10-03" @default.
• W2054194478 title "GM1-ganglioside-induced Aβ assembly on synaptic membranes of cultured neurons" @default.
• W2054194478 cites W1582745215 @default.
• W2054194478 cites W1660150417 @default.
• W2054194478 cites W1973033763 @default.
• W2054194478 cites W1978314140 @default.
• W2054194478 cites W1980522216 @default.
• W2054194478 cites W1982617198 @default.
• W2054194478 cites W1984086828 @default.
• W2054194478 cites W1989269014 @default.
• W2054194478 cites W1991717070 @default.
• W2054194478 cites W1994928619 @default.
• W2054194478 cites W2004748537 @default.
• W2054194478 cites W2006376420 @default.
• W2054194478 cites W2009196536 @default.
• W2054194478 cites W2009908869 @default.
• W2054194478 cites W2012129011 @default.
• W2054194478 cites W2013650907 @default.
• W2054194478 cites W2032189958 @default.
• W2054194478 cites W2037396758 @default.
• W2054194478 cites W2040016923 @default.
• W2054194478 cites W2050075457 @default.
• W2054194478 cites W2072858035 @default.
• W2054194478 cites W2082698296 @default.
• W2054194478 cites W2082807944 @default.
• W2054194478 cites W2087202514 @default.
• W2054194478 cites W2092552200 @default.
• W2054194478 cites W2092662963 @default.
• W2054194478 cites W2099077346 @default.
• W2054194478 cites W2112735281 @default.
• W2054194478 cites W2119297140 @default.
• W2054194478 cites W2123727994 @default.
• W2054194478 cites W2130079515 @default.
• W2054194478 cites W2142741152 @default.
• W2054194478 cites W2164727422 @default.
• W2054194478 cites W377222851 @default.
• W2054194478 doi "https://doi.org/10.1016/j.bbamem.2007.01.009" @default.
• W2054194478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17306220" @default.
• W2054194478 hasPublicationYear "2007" @default.
• W2054194478 type Work @default.
• W2054194478 sameAs 2054194478 @default.
• W2054194478 citedByCount "51" @default.
• W2054194478 countsByYear W20541944782012 @default.
• W2054194478 countsByYear W20541944782013 @default.
• W2054194478 countsByYear W20541944782014 @default.
• W2054194478 countsByYear W20541944782015 @default.
• W2054194478 countsByYear W20541944782016 @default.
• W2054194478 countsByYear W20541944782017 @default.
• W2054194478 countsByYear W20541944782018 @default.
• W2054194478 countsByYear W20541944782019 @default.
• W2054194478 countsByYear W20541944782020 @default.
• W2054194478 countsByYear W20541944782022 @default.
• W2054194478 countsByYear W20541944782023 @default.
• W2054194478 crossrefType "journal-article" @default.
• W2054194478 hasAuthorship W2054194478A5010466289 @default.
• W2054194478 hasAuthorship W2054194478A5022355683 @default.
• W2054194478 hasAuthorship W2054194478A5049284705 @default.
• W2054194478 hasAuthorship W2054194478A5058071088 @default.
• W2054194478 hasBestOaLocation W20541944781 @default.
• W2054194478 hasConcept C113246987 @default.
• W2054194478 hasConcept C134018914 @default.
• W2054194478 hasConcept C153911025 @default.
• W2054194478 hasConcept C185592680 @default.
• W2054194478 hasConcept C202751555 @default.
• W2054194478 hasConcept C203014093 @default.
• W2054194478 hasConcept C204232928 @default.
• W2054194478 hasConcept C2777006276 @default.
• W2054194478 hasConcept C2777209535 @default.
• W2054194478 hasConcept C2777331542 @default.
• W2054194478 hasConcept C55493867 @default.
• W2054194478 hasConcept C86803240 @default.
• W2054194478 hasConcept C95444343 @default.
• W2054194478 hasConceptScore W2054194478C113246987 @default.
• W2054194478 hasConceptScore W2054194478C134018914 @default.
• W2054194478 hasConceptScore W2054194478C153911025 @default.
• W2054194478 hasConceptScore W2054194478C185592680 @default.
• W2054194478 hasConceptScore W2054194478C202751555 @default.
• W2054194478 hasConceptScore W2054194478C203014093 @default.
• W2054194478 hasConceptScore W2054194478C204232928 @default.
• W2054194478 hasConceptScore W2054194478C2777006276 @default.
• W2054194478 hasConceptScore W2054194478C2777209535 @default.
• W2054194478 hasConceptScore W2054194478C2777331542 @default.
• W2054194478 hasConceptScore W2054194478C55493867 @default.
• W2054194478 hasConceptScore W2054194478C86803240 @default.
• W2054194478 hasConceptScore W2054194478C95444343 @default.
• W2054194478 hasFunder F4320320912 @default.
• W2054194478 hasFunder F4320324144 @default.
• W2054194478 hasIssue "5" @default.
• W2054194478 hasLocation W20541944781 @default.
• W2054194478 hasLocation W20541944782 @default.
• W2054194478 hasOpenAccess W2054194478 @default.

• next