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- W2054200468 abstract "•Growth hormone deficiency (GHD) may arise in patients with previous acromegaly as a consequence of overly effective neurosurgery and/or radiotherapy. •The insulin-tolerance test is the gold standard for diagnosis of GHD, and the response is independent of previous cranial irradiation for hypothalamic-pituitary tumors. •The GH releasing hormone+arginine test is as effective as the insulin-tolerance test for diagnosing GHD in acromegaly patients treated by neurosurgery, as well as in those treated by radiotherapy 5 years following irradiation. •Patients who develop GHD after treatment of acromegaly may have an impairment of cardiovascular health and quality of life. •The risk/benefit ratio of replacement therapy for GHD in patients with a history of acromegaly is still uncertain. Growth hormone deficiency (GHD) of the adult is characterized by reduced quality of life (QoL) and physical fitness, skeletal fragility, and increased weight and cardiovascular risk. Hypopituitarism may develop in patients after definitive treatment of acromegaly, but an exact prevalence of GHD in this population is still uncertain owing to limited awareness and the scarce and conflicting data available on this topic. Because acromegaly and GHD may yield adverse consequences on similar target systems, the final outcomes of some complications of acromegaly may be further affected by the occurrence of GHD. However, it is still largely unknown whether patients with post-acromegaly GHD may benefit from GH replacement. We review the diagnostic, clinical, and therapeutic aspects of GHD in adult patients treated for acromegaly. Growth hormone deficiency (GHD) of the adult is characterized by reduced quality of life (QoL) and physical fitness, skeletal fragility, and increased weight and cardiovascular risk. Hypopituitarism may develop in patients after definitive treatment of acromegaly, but an exact prevalence of GHD in this population is still uncertain owing to limited awareness and the scarce and conflicting data available on this topic. Because acromegaly and GHD may yield adverse consequences on similar target systems, the final outcomes of some complications of acromegaly may be further affected by the occurrence of GHD. However, it is still largely unknown whether patients with post-acromegaly GHD may benefit from GH replacement. We review the diagnostic, clinical, and therapeutic aspects of GHD in adult patients treated for acromegaly." @default.
- W2054200468 created "2016-06-24" @default.
- W2054200468 creator A5019524070 @default.
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- W2054200468 creator A5043401504 @default.
- W2054200468 creator A5048100872 @default.
- W2054200468 date "2015-01-01" @default.
- W2054200468 modified "2023-09-25" @default.
- W2054200468 title "Growth hormone deficiency in treated acromegaly" @default.
- W2054200468 cites W123434114 @default.
- W2054200468 cites W1482685153 @default.
- W2054200468 cites W1539318748 @default.
- W2054200468 cites W1965937894 @default.
- W2054200468 cites W1966131659 @default.
- W2054200468 cites W1966753183 @default.
- W2054200468 cites W1967507952 @default.
- W2054200468 cites W1967704619 @default.
- W2054200468 cites W1968009970 @default.
- W2054200468 cites W1969665744 @default.
- W2054200468 cites W1973361468 @default.
- W2054200468 cites W1977765716 @default.
- W2054200468 cites W1978148124 @default.
- W2054200468 cites W1978787511 @default.
- W2054200468 cites W1979553864 @default.
- W2054200468 cites W1979627788 @default.
- W2054200468 cites W1980088826 @default.
- W2054200468 cites W1996040533 @default.
- W2054200468 cites W1996218212 @default.
- W2054200468 cites W1996610858 @default.
- W2054200468 cites W1998850554 @default.
- W2054200468 cites W2002688486 @default.
- W2054200468 cites W2005859715 @default.
- W2054200468 cites W2007265160 @default.
- W2054200468 cites W2007956690 @default.
- W2054200468 cites W2011106362 @default.
- W2054200468 cites W2011162641 @default.
- W2054200468 cites W2014729851 @default.
- W2054200468 cites W2015040854 @default.
- W2054200468 cites W2018001968 @default.
- W2054200468 cites W2018480165 @default.
- W2054200468 cites W2021983698 @default.
- W2054200468 cites W2022874606 @default.
- W2054200468 cites W2023865686 @default.
- W2054200468 cites W2025551417 @default.
- W2054200468 cites W2035054580 @default.
- W2054200468 cites W2037846018 @default.
- W2054200468 cites W2038754029 @default.
- W2054200468 cites W2043750439 @default.
- W2054200468 cites W2045758709 @default.
- W2054200468 cites W2052576311 @default.
- W2054200468 cites W2059065431 @default.
- W2054200468 cites W2059465784 @default.
- W2054200468 cites W2060929608 @default.
- W2054200468 cites W2061748973 @default.
- W2054200468 cites W2062026358 @default.
- W2054200468 cites W2065218659 @default.
- W2054200468 cites W2069476119 @default.
- W2054200468 cites W2069900263 @default.
- W2054200468 cites W2076553711 @default.
- W2054200468 cites W2077055541 @default.
- W2054200468 cites W2083097965 @default.
- W2054200468 cites W2083102026 @default.
- W2054200468 cites W2084090215 @default.
- W2054200468 cites W2088031764 @default.
- W2054200468 cites W2090627812 @default.
- W2054200468 cites W2093931036 @default.
- W2054200468 cites W2095591038 @default.
- W2054200468 cites W2096131890 @default.
- W2054200468 cites W2100836119 @default.
- W2054200468 cites W2101260996 @default.
- W2054200468 cites W2102911655 @default.
- W2054200468 cites W2103849796 @default.
- W2054200468 cites W2105041056 @default.
- W2054200468 cites W2105233774 @default.
- W2054200468 cites W2108145636 @default.
- W2054200468 cites W2109123900 @default.
- W2054200468 cites W2110254569 @default.
- W2054200468 cites W2110780051 @default.
- W2054200468 cites W2112965103 @default.
- W2054200468 cites W2115440430 @default.
- W2054200468 cites W2118793476 @default.
- W2054200468 cites W2122247204 @default.
- W2054200468 cites W2123997600 @default.
- W2054200468 cites W2126572860 @default.
- W2054200468 cites W2126573384 @default.
- W2054200468 cites W2126577076 @default.
- W2054200468 cites W2130890130 @default.
- W2054200468 cites W2130988832 @default.
- W2054200468 cites W2132094049 @default.
- W2054200468 cites W2134166265 @default.
- W2054200468 cites W2135480490 @default.
- W2054200468 cites W2136359274 @default.
- W2054200468 cites W2136897044 @default.
- W2054200468 cites W2137300166 @default.
- W2054200468 cites W2138577756 @default.
- W2054200468 cites W2139034226 @default.
- W2054200468 cites W2141409443 @default.