FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054201822> ?p ?o ?g. }

• W2054201822 endingPage "391" @default.
• W2054201822 startingPage "380" @default.
• W2054201822 abstract "It is shown that the equilibrium transmembrane lipid asymmetry strongly depends on the degree of nonideality in the lateral mixing of the lipid components. In two-component bilayers the effect of nonideal lateral mixing is maximal for a given component at mole fractions of this component between 0.35 and 0.4. For asymmetry creating factors about 3 kT correcting for lateral nonidealities typical for lipids can increase as much as three times the transmembrane asymmetry. The relationship between lateral nonideality and transbilayer asymmetry is analysed in detail in the case of electrostatically induced asymmetry by using the Gouy-Chapman theory of electric double layers and the Bragg-Williams (regular solutions) approximation of nonideal lateral mixing. Two representative models are studied: (a) a single flat bilayer with a transmembrane electric potential difference applied on it; (b) two parallel membranes at short separation. In case (a), for transmembrane potentials of about 50-100 mV the introduction of nonideality corrections increases up to 40% the transmembrane asymmetry. In case (b), at physiological electrolyte concentrations the lipid asymmetry and, consequently, the effect of lateral nonideality become significant only at unrealistically small separations between the membranes. The surprisingly great influence of the lateral nonideality on the equilibrium transmembrane asymmetry suggests a significant role for this effect in determining the membrane molecular organization. A restricted lateral lipid miscibility might serve as a peculiar, but rather strong 'amplifier' of the transmembrane asymmetry. The qualitatively different asymmetries found in small unilamellar phosphatidylcholine-phosphatidylethanolamine vesicles of different fatty acid composition (Lentz, B.R. and Litman, B.J. (1978) Biochemistry 17, 5537-5543) can be reasonably well explained as an effect of the lateral nonideality. A hypothesis considering the transmembrane distributions of the major phospholipid species in erythrocytes as evolving from their lateral miscibilities is proposed." @default.
• W2054201822 created "2016-06-24" @default.
• W2054201822 creator A5022182739 @default.
• W2054201822 creator A5074169677 @default.
• W2054201822 date "1985-05-01" @default.
• W2054201822 modified "2023-10-17" @default.
• W2054201822 title "The effect of nonideal lateral mixing on the transmembrane lipid asymmetry" @default.
• W2054201822 cites W1607849218 @default.
• W2054201822 cites W1981020955 @default.
• W2054201822 cites W1987066037 @default.
• W2054201822 cites W1994583860 @default.
• W2054201822 cites W1996883801 @default.
• W2054201822 cites W1998353400 @default.
• W2054201822 cites W2001825873 @default.
• W2054201822 cites W2002660914 @default.
• W2054201822 cites W2018889102 @default.
• W2054201822 cites W2019625738 @default.
• W2054201822 cites W2021261140 @default.
• W2054201822 cites W2021968328 @default.
• W2054201822 cites W2022335022 @default.
• W2054201822 cites W2023991976 @default.
• W2054201822 cites W2027185770 @default.
• W2054201822 cites W2031180458 @default.
• W2054201822 cites W2040936229 @default.
• W2054201822 cites W2043947970 @default.
• W2054201822 cites W2050093743 @default.
• W2054201822 cites W2051228171 @default.
• W2054201822 cites W2051569540 @default.
• W2054201822 cites W2053615430 @default.
• W2054201822 cites W2054303473 @default.
• W2054201822 cites W2057464452 @default.
• W2054201822 cites W2062017627 @default.
• W2054201822 cites W2066232608 @default.
• W2054201822 cites W2070898798 @default.
• W2054201822 cites W2077854133 @default.
• W2054201822 cites W2083969639 @default.
• W2054201822 cites W2089721987 @default.
• W2054201822 cites W2091044472 @default.
• W2054201822 cites W2094926991 @default.
• W2054201822 cites W2165852855 @default.
• W2054201822 cites W2179142653 @default.
• W2054201822 cites W2012883918 @default.
• W2054201822 doi "https://doi.org/10.1016/0005-2736(85)90364-5" @default.
• W2054201822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3995033" @default.
• W2054201822 hasPublicationYear "1985" @default.
• W2054201822 type Work @default.
• W2054201822 sameAs 2054201822 @default.
• W2054201822 citedByCount "14" @default.
• W2054201822 countsByYear W20542018222022 @default.
• W2054201822 crossrefType "journal-article" @default.
• W2054201822 hasAuthorship W2054201822A5022182739 @default.
• W2054201822 hasAuthorship W2054201822A5074169677 @default.
• W2054201822 hasConcept C121332964 @default.
• W2054201822 hasConcept C12554922 @default.
• W2054201822 hasConcept C138777275 @default.
• W2054201822 hasConcept C170493617 @default.
• W2054201822 hasConcept C185592680 @default.
• W2054201822 hasConcept C24530287 @default.
• W2054201822 hasConcept C2776330855 @default.
• W2054201822 hasConcept C2778918659 @default.
• W2054201822 hasConcept C38976095 @default.
• W2054201822 hasConcept C39944091 @default.
• W2054201822 hasConcept C41625074 @default.
• W2054201822 hasConcept C55493867 @default.
• W2054201822 hasConcept C62520636 @default.
• W2054201822 hasConcept C86803240 @default.
• W2054201822 hasConceptScore W2054201822C121332964 @default.
• W2054201822 hasConceptScore W2054201822C12554922 @default.
• W2054201822 hasConceptScore W2054201822C138777275 @default.
• W2054201822 hasConceptScore W2054201822C170493617 @default.
• W2054201822 hasConceptScore W2054201822C185592680 @default.
• W2054201822 hasConceptScore W2054201822C24530287 @default.
• W2054201822 hasConceptScore W2054201822C2776330855 @default.
• W2054201822 hasConceptScore W2054201822C2778918659 @default.
• W2054201822 hasConceptScore W2054201822C38976095 @default.
• W2054201822 hasConceptScore W2054201822C39944091 @default.
• W2054201822 hasConceptScore W2054201822C41625074 @default.
• W2054201822 hasConceptScore W2054201822C55493867 @default.
• W2054201822 hasConceptScore W2054201822C62520636 @default.
• W2054201822 hasConceptScore W2054201822C86803240 @default.
• W2054201822 hasIssue "3" @default.
• W2054201822 hasLocation W20542018221 @default.
• W2054201822 hasLocation W20542018222 @default.
• W2054201822 hasOpenAccess W2054201822 @default.
• W2054201822 hasPrimaryLocation W20542018221 @default.
• W2054201822 hasRelatedWork W1970243421 @default.
• W2054201822 hasRelatedWork W1981375502 @default.
• W2054201822 hasRelatedWork W1995706914 @default.
• W2054201822 hasRelatedWork W2161536338 @default.
• W2054201822 hasRelatedWork W2563721932 @default.
• W2054201822 hasRelatedWork W2564117472 @default.
• W2054201822 hasRelatedWork W3025986755 @default.
• W2054201822 hasRelatedWork W3110055093 @default.
• W2054201822 hasRelatedWork W3171224921 @default.
• W2054201822 hasRelatedWork W4319928943 @default.
• W2054201822 hasVolume "815" @default.
• W2054201822 isParatext "false" @default.
• W2054201822 isRetracted "false" @default.

• next