FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054206673> ?p ?o ?g. }

• W2054206673 endingPage "2094" @default.
• W2054206673 startingPage "2087" @default.
• W2054206673 abstract "Abstract Enhanced expression of the HPV 16 E6‐E7 oncogenes may trigger neoplastic transformation of the squamous epithelial cells at the uterine cervix. The HPV E2 protein is a key transcriptional regulator of the E6‐E7 genes. It binds to four E2 binding sites (E2BSs 1–4) in the viral upstream regulatory region (URR). Modification of E2 functions, for example, by methylation of E2BSs is hypothesized to trigger enhanced expression of the viral E6‐E7 oncogenes. In the majority of HPV‐transformed premalignant lesions and about half of cervical carcinomas HPV genomes persist in an extra‐chromosomal, episomal state, whereas they are integrated into host cells chromosomes in the remaining lesions. Here we compared the methylation profile of E2BSs 1–4 of the HPV 16 URR in a series of 18 HPV16‐positive premalignant lesions and 33 invasive cervical cancers. CpGs within the E2BSs 1, 3, and 4 were higher methylated in all lesions with only episomal HPV16 genomes compared with lesions displaying single integrated copies. Samples with multiple HPV16 integrated copies displayed high methylation levels for all CpGs suggesting that the majority of multiple copies were silenced by extensive methylation. These data support the hypothesis that differential methylation of the E2BSs 1, 3 and 4 is related to the activation of viral oncogene expression in cervical lesions as long as the viral genome remains in the episomal state. Once the virus becomes integrated into host cell chromosomes these methylation patterns may be substantially altered due to complex epigenetic changes of integrated HPV genomes." @default.
• W2054206673 created "2016-06-24" @default.
• W2054206673 creator A5005941126 @default.
• W2054206673 creator A5007438121 @default.
• W2054206673 creator A5017825037 @default.
• W2054206673 creator A5024936471 @default.
• W2054206673 creator A5039863157 @default.
• W2054206673 creator A5048344126 @default.
• W2054206673 creator A5080442175 @default.
• W2054206673 creator A5088821017 @default.
• W2054206673 creator A5090913683 @default.
• W2054206673 creator A5091813615 @default.
• W2054206673 date "2012-11-26" @default.
• W2054206673 modified "2023-10-18" @default.
• W2054206673 title "Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions" @default.
• W2054206673 cites W1539426772 @default.
• W2054206673 cites W1569876593 @default.
• W2054206673 cites W1672426070 @default.
• W2054206673 cites W1767781328 @default.
• W2054206673 cites W1966481117 @default.
• W2054206673 cites W1973675115 @default.
• W2054206673 cites W1982808927 @default.
• W2054206673 cites W1994482344 @default.
• W2054206673 cites W1997612801 @default.
• W2054206673 cites W2002158439 @default.
• W2054206673 cites W2002936023 @default.
• W2054206673 cites W2004342441 @default.
• W2054206673 cites W2009504586 @default.
• W2054206673 cites W2012503416 @default.
• W2054206673 cites W2023942950 @default.
• W2054206673 cites W2034579809 @default.
• W2054206673 cites W2039382131 @default.
• W2054206673 cites W2041959453 @default.
• W2054206673 cites W2053954567 @default.
• W2054206673 cites W2054866600 @default.
• W2054206673 cites W2058802528 @default.
• W2054206673 cites W2060153909 @default.
• W2054206673 cites W2088025605 @default.
• W2054206673 cites W2089963048 @default.
• W2054206673 cites W2096109049 @default.
• W2054206673 cites W2096707280 @default.
• W2054206673 cites W2097999551 @default.
• W2054206673 cites W2098765233 @default.
• W2054206673 cites W2102994752 @default.
• W2054206673 cites W2103351598 @default.
• W2054206673 cites W2103954975 @default.
• W2054206673 cites W2107815610 @default.
• W2054206673 cites W2109892705 @default.
• W2054206673 cites W2113999862 @default.
• W2054206673 cites W2120244748 @default.
• W2054206673 cites W2123179912 @default.
• W2054206673 cites W2131459766 @default.
• W2054206673 cites W2139736159 @default.
• W2054206673 cites W2141641834 @default.
• W2054206673 cites W2143744957 @default.
• W2054206673 cites W2149838021 @default.
• W2054206673 cites W2151066134 @default.
• W2054206673 cites W2151895234 @default.
• W2054206673 cites W2158253659 @default.
• W2054206673 cites W2161167739 @default.
• W2054206673 cites W2164333690 @default.
• W2054206673 cites W2169232033 @default.
• W2054206673 cites W2170918168 @default.
• W2054206673 doi "https://doi.org/10.1002/ijc.27906" @default.
• W2054206673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23065631" @default.
• W2054206673 hasPublicationYear "2012" @default.
• W2054206673 type Work @default.
• W2054206673 sameAs 2054206673 @default.
• W2054206673 citedByCount "86" @default.
• W2054206673 countsByYear W20542066732013 @default.
• W2054206673 countsByYear W20542066732014 @default.
• W2054206673 countsByYear W20542066732015 @default.
• W2054206673 countsByYear W20542066732016 @default.
• W2054206673 countsByYear W20542066732017 @default.
• W2054206673 countsByYear W20542066732018 @default.
• W2054206673 countsByYear W20542066732019 @default.
• W2054206673 countsByYear W20542066732020 @default.
• W2054206673 countsByYear W20542066732021 @default.
• W2054206673 countsByYear W20542066732022 @default.
• W2054206673 countsByYear W20542066732023 @default.
• W2054206673 crossrefType "journal-article" @default.
• W2054206673 hasAuthorship W2054206673A5005941126 @default.
• W2054206673 hasAuthorship W2054206673A5007438121 @default.
• W2054206673 hasAuthorship W2054206673A5017825037 @default.
• W2054206673 hasAuthorship W2054206673A5024936471 @default.
• W2054206673 hasAuthorship W2054206673A5039863157 @default.
• W2054206673 hasAuthorship W2054206673A5048344126 @default.
• W2054206673 hasAuthorship W2054206673A5080442175 @default.
• W2054206673 hasAuthorship W2054206673A5088821017 @default.
• W2054206673 hasAuthorship W2054206673A5090913683 @default.
• W2054206673 hasAuthorship W2054206673A5091813615 @default.
• W2054206673 hasConcept C104317684 @default.
• W2054206673 hasConcept C141231307 @default.
• W2054206673 hasConcept C150194340 @default.
• W2054206673 hasConcept C153911025 @default.
• W2054206673 hasConcept C159047783 @default.
• W2054206673 hasConcept C190727270 @default.
• W2054206673 hasConcept C2910786375 @default.

• next