FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054206875> ?p ?o ?g. }

• W2054206875 endingPage "D944" @default.
• W2054206875 startingPage "D939" @default.
• W2054206875 abstract "Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and function. Therefore, it is crucial to understand the trilateral relationship among genomic variations, diseases and drugs. We present the variations and drugs (VnD), a consolidated database containing information on diseases, related genes and genetic variations, protein structures and drug information. VnD was built in three steps. First, we integrated various resources systematically to deduce catalogs of disease-related genes, single nucleotide polymorphisms (SNPs), protein mutations and relevant drugs. VnD contains 137 195 disease-related gene records (13 940 distinct genes) and 16 586 genetic variation records (1790 distinct variations). Next, we carried out structure modeling and docking simulation for wild-type and mutant proteins to examine the structural and functional consequences of non-synonymous SNPs in the drug-related genes. Conformational changes in 590 wild-type and 4437 mutant proteins from drug-related genes were included in our database. Finally, we investigated the structural and biochemical properties relevant to drug binding such as the distribution of SNPs in proximal protein pockets, thermo-chemical stability, interactions with drugs and physico-chemical properties. The VnD database, available at http://vnd.kobic.re.kr:8080/VnD/ or vandd.org, would be a useful platform for researchers studying the underlying mechanism for association among genetic variations, diseases and drugs." @default.
• W2054206875 created "2016-06-24" @default.
• W2054206875 creator A5002739553 @default.
• W2054206875 creator A5011378471 @default.
• W2054206875 creator A5030041708 @default.
• W2054206875 creator A5037685409 @default.
• W2054206875 creator A5043106210 @default.
• W2054206875 creator A5058778185 @default.
• W2054206875 creator A5088265005 @default.
• W2054206875 date "2010-11-04" @default.
• W2054206875 modified "2023-09-27" @default.
• W2054206875 title "VnD: a structure-centric database of disease-related SNPs and drugs" @default.
• W2054206875 cites W1973969603 @default.
• W2054206875 cites W1976500765 @default.
• W2054206875 cites W1995808589 @default.
• W2054206875 cites W2003932708 @default.
• W2054206875 cites W2009313526 @default.
• W2054206875 cites W2020418945 @default.
• W2054206875 cites W2023768068 @default.
• W2054206875 cites W2031194866 @default.
• W2054206875 cites W2048296798 @default.
• W2054206875 cites W2051877901 @default.
• W2054206875 cites W2055043387 @default.
• W2054206875 cites W2058401000 @default.
• W2054206875 cites W2059145105 @default.
• W2054206875 cites W2081124533 @default.
• W2054206875 cites W2098767742 @default.
• W2054206875 cites W2100323336 @default.
• W2054206875 cites W2100428244 @default.
• W2054206875 cites W2108376320 @default.
• W2054206875 cites W2119412782 @default.
• W2054206875 cites W2125203512 @default.
• W2054206875 cites W2125792789 @default.
• W2054206875 cites W2127230663 @default.
• W2054206875 cites W2129556489 @default.
• W2054206875 cites W2132606212 @default.
• W2054206875 cites W2136513422 @default.
• W2054206875 cites W2141066255 @default.
• W2054206875 cites W2145477956 @default.
• W2054206875 cites W2158057897 @default.
• W2054206875 cites W2159583324 @default.
• W2054206875 cites W2160993714 @default.
• W2054206875 cites W2165526004 @default.
• W2054206875 cites W2213366305 @default.
• W2054206875 cites W2916427899 @default.
• W2054206875 cites W4239678514 @default.
• W2054206875 cites W4245803912 @default.
• W2054206875 cites W4254753097 @default.
• W2054206875 doi "https://doi.org/10.1093/nar/gkq957" @default.
• W2054206875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3013797" @default.
• W2054206875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21051351" @default.
• W2054206875 hasPublicationYear "2010" @default.
• W2054206875 type Work @default.
• W2054206875 sameAs 2054206875 @default.
• W2054206875 citedByCount "10" @default.
• W2054206875 countsByYear W20542068752012 @default.
• W2054206875 countsByYear W20542068752013 @default.
• W2054206875 countsByYear W20542068752014 @default.
• W2054206875 countsByYear W20542068752017 @default.
• W2054206875 countsByYear W20542068752018 @default.
• W2054206875 countsByYear W20542068752019 @default.
• W2054206875 countsByYear W20542068752020 @default.
• W2054206875 crossrefType "journal-article" @default.
• W2054206875 hasAuthorship W2054206875A5002739553 @default.
• W2054206875 hasAuthorship W2054206875A5011378471 @default.
• W2054206875 hasAuthorship W2054206875A5030041708 @default.
• W2054206875 hasAuthorship W2054206875A5037685409 @default.
• W2054206875 hasAuthorship W2054206875A5043106210 @default.
• W2054206875 hasAuthorship W2054206875A5058778185 @default.
• W2054206875 hasAuthorship W2054206875A5088265005 @default.
• W2054206875 hasBestOaLocation W20542068751 @default.
• W2054206875 hasConcept C104317684 @default.
• W2054206875 hasConcept C111472728 @default.
• W2054206875 hasConcept C135763542 @default.
• W2054206875 hasConcept C138885662 @default.
• W2054206875 hasConcept C143065580 @default.
• W2054206875 hasConcept C153209595 @default.
• W2054206875 hasConcept C2780035454 @default.
• W2054206875 hasConcept C41008148 @default.
• W2054206875 hasConcept C501734568 @default.
• W2054206875 hasConcept C54355233 @default.
• W2054206875 hasConcept C68873052 @default.
• W2054206875 hasConcept C70721500 @default.
• W2054206875 hasConcept C77088390 @default.
• W2054206875 hasConcept C86803240 @default.
• W2054206875 hasConcept C89611455 @default.
• W2054206875 hasConcept C98274493 @default.
• W2054206875 hasConceptScore W2054206875C104317684 @default.
• W2054206875 hasConceptScore W2054206875C111472728 @default.
• W2054206875 hasConceptScore W2054206875C135763542 @default.
• W2054206875 hasConceptScore W2054206875C138885662 @default.
• W2054206875 hasConceptScore W2054206875C143065580 @default.
• W2054206875 hasConceptScore W2054206875C153209595 @default.
• W2054206875 hasConceptScore W2054206875C2780035454 @default.
• W2054206875 hasConceptScore W2054206875C41008148 @default.
• W2054206875 hasConceptScore W2054206875C501734568 @default.
• W2054206875 hasConceptScore W2054206875C54355233 @default.
• W2054206875 hasConceptScore W2054206875C68873052 @default.

• next