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- W2054218356 abstract "Dynamic contrast enhanced (DCE) MR imaging is emerging as a promising biomarker for therapy assessment. While initial results from research groups are promising, a significant gap exists between preliminary research studies and practical utilization. In addition to variations in data acquired from different image acquisition techniques, a large variety of pharmacokinetic models have been explored from which to derive quantitative metrics. Examples of such models include those from Patlack, Toft, and Elizabeth, with a number of others in use in various research groups. These models have various levels of complexity, which in general is inversely related to the robustness with which the models perform on imaging data. Furthermore, the selection of an optimal pharmacokinetic model may be highly dependent on the tissue or organ being investigated. Currently, a national effort is underway to help standardize the extraction of physiological parameters from DCE‐MRI and related pharmacokinetic models. This talk explores these issues, comparing various models and their performance, and provides an overview of the areas that need consideration prior to widespread adoption of DCE‐MRI derived model parameters as assessment tools. Learning Objectives: 1. Understand the strengths and weaknesses of commonly used pharmacokinetic models 2. Understand the influence of image acquisition parameters and image quality on derived quantitative metrics 3. Provide examples of clinical applications" @default.
- W2054218356 created "2016-06-24" @default.
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- W2054218356 date "2009-06-01" @default.
- W2054218356 modified "2023-09-22" @default.
- W2054218356 title "WE-A-303A-01: DCE MRI for Quantitative Assessment of Therapy Response" @default.
- W2054218356 doi "https://doi.org/10.1118/1.3182448" @default.
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