Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054226143> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2054226143 endingPage "1032" @default.
- W2054226143 startingPage "1028" @default.
- W2054226143 abstract "This report demonstrates for the first time that indirect T cell allorecognition of donor antigens can contribute to the effector mechanism of rejection of vascularized organ allografts. LEW (RT11) rats were primed for indirect T cell allorecognition of DA (RTlavl) classical class I MHC molecules by immunization with synthetic 22-24 amino acid peptides corresponding to the a-helices of the RT1-A class I molecule. These rats received (DA × LEW) F1 kidney grafts that had been depleted of donor interstitial dendritic cells to minimize the direct T cell allorecognition response to the graft. The peptide-immunized rats rejected their grafts more rapidly than did control immunized rats, in terms of both graft function and survival. Moreover, the kinetics of antibody production to intact donor class I molecules after kidney transplantation was much more rapid in the peptide-immunized rats, suggesting that T cell help is the rate-limiting factor for antibody production to donor antigens in this model. It was of interest that we could not detect an antibody response to donor peptides after kidney graft rejection." @default.
- W2054226143 created "2016-06-24" @default.
- W2054226143 creator A5015624912 @default.
- W2054226143 creator A5031575424 @default.
- W2054226143 creator A5074401427 @default.
- W2054226143 date "1995-04-01" @default.
- W2054226143 modified "2023-09-23" @default.
- W2054226143 title "INDIRECT T CELL ALLORECOGNITION OF DONOR ANTIGENS CONTRIBUTES TO THE REJECTION OF VASCULARIZED KIDNEY ALLOGRAFTS" @default.
- W2054226143 doi "https://doi.org/10.1097/00007890-199504150-00019" @default.
- W2054226143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7709439" @default.
- W2054226143 hasPublicationYear "1995" @default.
- W2054226143 type Work @default.
- W2054226143 sameAs 2054226143 @default.
- W2054226143 citedByCount "73" @default.
- W2054226143 countsByYear W20542261432013 @default.
- W2054226143 countsByYear W20542261432016 @default.
- W2054226143 crossrefType "journal-article" @default.
- W2054226143 hasAuthorship W2054226143A5015624912 @default.
- W2054226143 hasAuthorship W2054226143A5031575424 @default.
- W2054226143 hasAuthorship W2054226143A5074401427 @default.
- W2054226143 hasBestOaLocation W20542261431 @default.
- W2054226143 hasConcept C126322002 @default.
- W2054226143 hasConcept C134018914 @default.
- W2054226143 hasConcept C147483822 @default.
- W2054226143 hasConcept C159654299 @default.
- W2054226143 hasConcept C188280979 @default.
- W2054226143 hasConcept C200315206 @default.
- W2054226143 hasConcept C202965653 @default.
- W2054226143 hasConcept C203014093 @default.
- W2054226143 hasConcept C207936829 @default.
- W2054226143 hasConcept C2776090121 @default.
- W2054226143 hasConcept C2780091579 @default.
- W2054226143 hasConcept C2911091166 @default.
- W2054226143 hasConcept C71924100 @default.
- W2054226143 hasConcept C86803240 @default.
- W2054226143 hasConcept C8891405 @default.
- W2054226143 hasConceptScore W2054226143C126322002 @default.
- W2054226143 hasConceptScore W2054226143C134018914 @default.
- W2054226143 hasConceptScore W2054226143C147483822 @default.
- W2054226143 hasConceptScore W2054226143C159654299 @default.
- W2054226143 hasConceptScore W2054226143C188280979 @default.
- W2054226143 hasConceptScore W2054226143C200315206 @default.
- W2054226143 hasConceptScore W2054226143C202965653 @default.
- W2054226143 hasConceptScore W2054226143C203014093 @default.
- W2054226143 hasConceptScore W2054226143C207936829 @default.
- W2054226143 hasConceptScore W2054226143C2776090121 @default.
- W2054226143 hasConceptScore W2054226143C2780091579 @default.
- W2054226143 hasConceptScore W2054226143C2911091166 @default.
- W2054226143 hasConceptScore W2054226143C71924100 @default.
- W2054226143 hasConceptScore W2054226143C86803240 @default.
- W2054226143 hasConceptScore W2054226143C8891405 @default.
- W2054226143 hasIssue "7" @default.
- W2054226143 hasLocation W20542261431 @default.
- W2054226143 hasLocation W20542261432 @default.
- W2054226143 hasLocation W20542261433 @default.
- W2054226143 hasOpenAccess W2054226143 @default.
- W2054226143 hasPrimaryLocation W20542261431 @default.
- W2054226143 hasRelatedWork W1983700947 @default.
- W2054226143 hasRelatedWork W2026564383 @default.
- W2054226143 hasRelatedWork W2038798641 @default.
- W2054226143 hasRelatedWork W2056553475 @default.
- W2054226143 hasRelatedWork W2060168633 @default.
- W2054226143 hasRelatedWork W2087762146 @default.
- W2054226143 hasRelatedWork W2399118869 @default.
- W2054226143 hasRelatedWork W2409048642 @default.
- W2054226143 hasRelatedWork W2413127638 @default.
- W2054226143 hasRelatedWork W4238201290 @default.
- W2054226143 hasVolume "59" @default.
- W2054226143 isParatext "false" @default.
- W2054226143 isRetracted "false" @default.
- W2054226143 magId "2054226143" @default.
- W2054226143 workType "article" @default.