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- W2054227456 endingPage "103" @default.
- W2054227456 startingPage "92" @default.
- W2054227456 abstract "The hematopoietic system is dynamic during development and in adulthood, undergoing countless spatial and temporal transitions during the course of one's life. Microenvironmental cues in the many unique hematopoietic niches differ, characterized by distinct soluble molecules, membrane-bound factors, and biophysical features that meet the changing needs of the blood system. Research from the last decade has revealed the importance of substrate elasticity and biomechanical force in determination of stem cell fate. Our understanding of the role of these factors in hematopoiesis is still relatively poor; however, the developmental origin of blood cells from the endothelium provides a model for comparison. Many endothelial mechanical sensors and second messenger systems may also determine hematopoietic stem cell fate, self renewal, and homing behaviors. Further, the intimate contact of hematopoietic cells with mechanosensitive cell types, including osteoblasts, endothelial cells, mesenchymal stem cells, and pericytes, places them in close proximity to paracrine signaling downstream of mechanical signals. The objective of this review is to present an overview of the sensors and intracellular signaling pathways activated by mechanical cues and highlight the role of mechanotransductive pathways in hematopoiesis." @default.
- W2054227456 created "2016-06-24" @default.
- W2054227456 creator A5014958403 @default.
- W2054227456 creator A5015105154 @default.
- W2054227456 creator A5038177541 @default.
- W2054227456 creator A5066397554 @default.
- W2054227456 creator A5069464430 @default.
- W2054227456 date "2013-10-01" @default.
- W2054227456 modified "2023-09-28" @default.
- W2054227456 title "Biomechanical force in blood development: Extrinsic physical cues drive pro-hematopoietic signaling" @default.
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