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- W2054233291 abstract "Ataxia, weakness and changes in peripheral sensitivity are consequences of vitamin B-6 deficiency. This experiment was conducted to quantify these effects, using tests commonly employed in toxicology studies. Female Long-Evans rats (mean weight=232g) were blocked by weight into 3 treatment groups (n=12): AL-CON, fed AIN-76A diet ad libitum; DEF, fed the same diet devoid of pyridoxine; and PF-CON, pair-fed to DEF. Motor function was evaluated with hindleg gait analysis, grip-strength, and whole-body pull-up. Sensory function was evaluated using tail-flick and landing foot-spread. Deficiency was detected with a tryptophan-load test on day 9 of a simultaneous experiment with an identical feeding protocol. On day 9, abnormalities were detected and quantified by gait analysis—angle and width of step were affected by diet (P<0.05) although there were no differences in body weights and food intakes at that time. The overall effect of diet on angle and width was highly significant (P<0.001). Food intake of DEF was depressed by week 2; at week 10, body weight and feed efficiencies were significantly different among groups. Except for a transient effect on tail-flick, no other test was affected by diet. Gait analysis may have potential as an index of vitamin B-6 status under these experimental conditions." @default.
- W2054233291 created "2016-06-24" @default.
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- W2054233291 date "1987-08-01" @default.
- W2054233291 modified "2023-09-26" @default.
- W2054233291 title "Quantitative assessment of motor and sensory function in vitamin B-6 deficient rats" @default.
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