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- W2054241594 abstract "Chiral fluorinated hydroxyketones were synthesized with excellent ee (>98%) and yield by a chemo- and stereoselective reduction of prochiral methyl/trifluoromethyl diketones using commercially available ketoreductase enzymes. By using p- and m-trifluoroacetyl substituted acetophenones, we demonstrate that ketoreductases can selectively differentiate between methyl and trifluoromethyl ketones within the same molecule. As a result, useful catalysts were identified that eliminated the need for costly and time-consuming protection/deprotection of the ketone moiety, enabling a more convergent synthesis of hydroxyketones. Further, a route to chiral methyl hydroxyketones is provided where an enzyme selectively reduces the unactivated ketone." @default.
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- W2054241594 date "2007-10-31" @default.
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- W2054241594 title "Chemo- and Enantioselective Routes to Chiral Fluorinated Hydroxyketones Using Ketoreductases" @default.
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- W2054241594 doi "https://doi.org/10.1021/ol701810v" @default.
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