FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054241888> ?p ?o ?g. }

• W2054241888 endingPage "288" @default.
• W2054241888 startingPage "283" @default.
• W2054241888 abstract "The phosphodiesterase-III (PDE-III) inhibitor enoximone-induced marked contractures in skeletal muscle specimens of malignant hyperthermia (MH) susceptible (MHS) human beings and swine. Whether this is a substance specific effect of enoximone or caused by inhibition of PDE-III remained unclear. Therefore, the effects of the PDE-III inhibitor amrinone in porcine MH normal (MHN) and MHS skeletal muscles were investigated.MH-trigger-free general anaesthesia was performed in eight MHS and eight MHN swine. The MH status of the swine was determined by detection of the Arg615-Cys point mutation on chromosome 6 indicating MH susceptibility. Skeletal muscle specimens were excised for the in vitro contracture tests with amrinone. Amrinone was added cumulatively every 5 min to muscle specimens in order to obtain organ bath concentrations between 20 and 400 micromol L(-1). The in vitro effects of amrinone on muscle contractures and twitches were measured.Amrinone-induced contractures in all skeletal muscle preparations. MHS muscles developed contractures at significantly lower bath concentrations of amrinone than MHN muscles. Contractures of MHS compared to MHN muscles were significantly larger at bath concentrations of 80, 100, 150, 200 and 400 micromol L(-1) amrinone. Muscle twitches remained unchanged up to and including 200 micromol L(-1) amrinone.Inhibition of PDE-III in general elicited higher contractures in MHS than in MHN muscles. Therefore, a contribution of PDE-III and the cyclic adenosine monophosphate (cAMP) system in the pathophysiology of MH must be suspected." @default.
• W2054241888 created "2016-06-24" @default.
• W2054241888 creator A5002163808 @default.
• W2054241888 creator A5023361214 @default.
• W2054241888 creator A5044589108 @default.
• W2054241888 creator A5058641800 @default.
• W2054241888 creator A5062075233 @default.
• W2054241888 creator A5076992463 @default.
• W2054241888 date "2005-04-01" @default.
• W2054241888 modified "2023-10-09" @default.
• W2054241888 title "Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine" @default.
• W2054241888 cites W1964316581 @default.
• W2054241888 cites W1967904431 @default.
• W2054241888 cites W1968133040 @default.
• W2054241888 cites W1968408785 @default.
• W2054241888 cites W1978458147 @default.
• W2054241888 cites W1982367528 @default.
• W2054241888 cites W2034044880 @default.
• W2054241888 cites W2037442501 @default.
• W2054241888 cites W2048551240 @default.
• W2054241888 cites W2054050959 @default.
• W2054241888 cites W2061537934 @default.
• W2054241888 cites W2080907632 @default.
• W2054241888 cites W2111676966 @default.
• W2054241888 cites W2130381329 @default.
• W2054241888 cites W2136779301 @default.
• W2054241888 cites W2140152140 @default.
• W2054241888 cites W2141547153 @default.
• W2054241888 cites W2145503422 @default.
• W2054241888 cites W2147428652 @default.
• W2054241888 cites W2319499853 @default.
• W2054241888 cites W2340041051 @default.
• W2054241888 cites W4211153925 @default.
• W2054241888 cites W4235081482 @default.
• W2054241888 doi "https://doi.org/10.1017/s0265021505000475" @default.
• W2054241888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15892406" @default.
• W2054241888 hasPublicationYear "2005" @default.
• W2054241888 type Work @default.
• W2054241888 sameAs 2054241888 @default.
• W2054241888 citedByCount "9" @default.
• W2054241888 countsByYear W20542418882012 @default.
• W2054241888 countsByYear W20542418882018 @default.
• W2054241888 crossrefType "journal-article" @default.
• W2054241888 hasAuthorship W2054241888A5002163808 @default.
• W2054241888 hasAuthorship W2054241888A5023361214 @default.
• W2054241888 hasAuthorship W2054241888A5044589108 @default.
• W2054241888 hasAuthorship W2054241888A5058641800 @default.
• W2054241888 hasAuthorship W2054241888A5062075233 @default.
• W2054241888 hasAuthorship W2054241888A5076992463 @default.
• W2054241888 hasBestOaLocation W20542418881 @default.
• W2054241888 hasConcept C105702510 @default.
• W2054241888 hasConcept C126322002 @default.
• W2054241888 hasConcept C127607297 @default.
• W2054241888 hasConcept C134018914 @default.
• W2054241888 hasConcept C141071460 @default.
• W2054241888 hasConcept C178853913 @default.
• W2054241888 hasConcept C181199279 @default.
• W2054241888 hasConcept C185592680 @default.
• W2054241888 hasConcept C2776050358 @default.
• W2054241888 hasConcept C2776937108 @default.
• W2054241888 hasConcept C2778575482 @default.
• W2054241888 hasConcept C2779739782 @default.
• W2054241888 hasConcept C2779959927 @default.
• W2054241888 hasConcept C2780529135 @default.
• W2054241888 hasConcept C42219234 @default.
• W2054241888 hasConcept C55493867 @default.
• W2054241888 hasConcept C62826618 @default.
• W2054241888 hasConcept C71924100 @default.
• W2054241888 hasConceptScore W2054241888C105702510 @default.
• W2054241888 hasConceptScore W2054241888C126322002 @default.
• W2054241888 hasConceptScore W2054241888C127607297 @default.
• W2054241888 hasConceptScore W2054241888C134018914 @default.
• W2054241888 hasConceptScore W2054241888C141071460 @default.
• W2054241888 hasConceptScore W2054241888C178853913 @default.
• W2054241888 hasConceptScore W2054241888C181199279 @default.
• W2054241888 hasConceptScore W2054241888C185592680 @default.
• W2054241888 hasConceptScore W2054241888C2776050358 @default.
• W2054241888 hasConceptScore W2054241888C2776937108 @default.
• W2054241888 hasConceptScore W2054241888C2778575482 @default.
• W2054241888 hasConceptScore W2054241888C2779739782 @default.
• W2054241888 hasConceptScore W2054241888C2779959927 @default.
• W2054241888 hasConceptScore W2054241888C2780529135 @default.
• W2054241888 hasConceptScore W2054241888C42219234 @default.
• W2054241888 hasConceptScore W2054241888C55493867 @default.
• W2054241888 hasConceptScore W2054241888C62826618 @default.
• W2054241888 hasConceptScore W2054241888C71924100 @default.
• W2054241888 hasIssue "4" @default.
• W2054241888 hasLocation W20542418881 @default.
• W2054241888 hasLocation W20542418882 @default.
• W2054241888 hasLocation W20542418883 @default.
• W2054241888 hasOpenAccess W2054241888 @default.
• W2054241888 hasPrimaryLocation W20542418881 @default.
• W2054241888 hasRelatedWork W1976057366 @default.
• W2054241888 hasRelatedWork W2018991587 @default.
• W2054241888 hasRelatedWork W2033963815 @default.
• W2054241888 hasRelatedWork W2034746941 @default.
• W2054241888 hasRelatedWork W2076455248 @default.
• W2054241888 hasRelatedWork W2082905939 @default.

• next