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• W2054242699 abstract "Purpose/Objective(s)The accuracy of image co-registration is central to the use of multi-modality imaging to improve radiation therapy target definition. Validation of deformable image co-registration is essential prior to clinical implementation. A multi-modality imaging study is ongoing at our institution to investigate the role of MRI in GTV and OAR delineation for head and neck cancer radiation therapy. The aim of this current study is to evaluate the accuracy of deformable image co-registration.Materials/MethodsThe initial 5 study patients underwent a planning CT scan (pCT) followed by pre-treatment T1-weighted MRI scans both with (iMRI) and without (MRI) immobilization during a single imaging session. The images were paired as follows: pCT to iMRI, pCT to MRI and iMRI to MRI with co-registration achieved using an initial manual rigid body registration followed by an automated deformable registration using commercial software. The accuracy of co-registration was determined by the distance-to-agreement (DTA) of 7 anatomical landmarks. The landmarks were both orbits and ascending rami of the mandibles, the odontoid peg and the C4 and C6 vertebral bodies; these were chosen to cover the anatomy of interest and are easily identified on both imaging modalities. DTAs were found by a second researcher and compared using a heteroscedastic Student's t-test.ResultsDTAs for the 5 registrations from each group are given in the Table.ConclusionsPoster Viewing Abstract 3369; TableMean and maximum DTAs for all landmarks across all co-registered imaging pairsDistance to agreement (mm)Left orbitRight orbitLeft ascending ramusRight ascending ramusOdontoid pegC4C6MeanMeanpCT-iMRI1.52.21.01.92.12.01.91.7pCT-MRI1.72.13.74.12.36.55.63.5iMRI-MRI1.31.42.21.60.71.50.81.4MaxpCT-iMRI2.95.02.72.72.83.12.7-pCT-MRI3.13.59.46.83.712.89.3-iMRI-MRI2.52.24.13.32.32.42.3- Open table in a new tab Purpose/Objective(s)The accuracy of image co-registration is central to the use of multi-modality imaging to improve radiation therapy target definition. Validation of deformable image co-registration is essential prior to clinical implementation. A multi-modality imaging study is ongoing at our institution to investigate the role of MRI in GTV and OAR delineation for head and neck cancer radiation therapy. The aim of this current study is to evaluate the accuracy of deformable image co-registration. The accuracy of image co-registration is central to the use of multi-modality imaging to improve radiation therapy target definition. Validation of deformable image co-registration is essential prior to clinical implementation. A multi-modality imaging study is ongoing at our institution to investigate the role of MRI in GTV and OAR delineation for head and neck cancer radiation therapy. The aim of this current study is to evaluate the accuracy of deformable image co-registration. Materials/MethodsThe initial 5 study patients underwent a planning CT scan (pCT) followed by pre-treatment T1-weighted MRI scans both with (iMRI) and without (MRI) immobilization during a single imaging session. The images were paired as follows: pCT to iMRI, pCT to MRI and iMRI to MRI with co-registration achieved using an initial manual rigid body registration followed by an automated deformable registration using commercial software. The accuracy of co-registration was determined by the distance-to-agreement (DTA) of 7 anatomical landmarks. The landmarks were both orbits and ascending rami of the mandibles, the odontoid peg and the C4 and C6 vertebral bodies; these were chosen to cover the anatomy of interest and are easily identified on both imaging modalities. DTAs were found by a second researcher and compared using a heteroscedastic Student's t-test. The initial 5 study patients underwent a planning CT scan (pCT) followed by pre-treatment T1-weighted MRI scans both with (iMRI) and without (MRI) immobilization during a single imaging session. The images were paired as follows: pCT to iMRI, pCT to MRI and iMRI to MRI with co-registration achieved using an initial manual rigid body registration followed by an automated deformable registration using commercial software. The accuracy of co-registration was determined by the distance-to-agreement (DTA) of 7 anatomical landmarks. The landmarks were both orbits and ascending rami of the mandibles, the odontoid peg and the C4 and C6 vertebral bodies; these were chosen to cover the anatomy of interest and are easily identified on both imaging modalities. DTAs were found by a second researcher and compared using a heteroscedastic Student's t-test. ResultsDTAs for the 5 registrations from each group are given in the Table. DTAs for the 5 registrations from each group are given in the Table. ConclusionsPoster Viewing Abstract 3369; TableMean and maximum DTAs for all landmarks across all co-registered imaging pairsDistance to agreement (mm)Left orbitRight orbitLeft ascending ramusRight ascending ramusOdontoid pegC4C6MeanMeanpCT-iMRI1.52.21.01.92.12.01.91.7pCT-MRI1.72.13.74.12.36.55.63.5iMRI-MRI1.31.42.21.60.71.50.81.4MaxpCT-iMRI2.95.02.72.72.83.12.7-pCT-MRI3.13.59.46.83.712.89.3-iMRI-MRI2.52.24.13.32.32.42.3- Open table in a new tab" @default.
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• W2054242699 date "2012-11-01" @default.
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• W2054242699 title "Assessment of the Benefit of MRI Immobilization for Deformable Image Coregistration for Head and Neck Radiation Therapy Planning" @default.
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