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- W2054244025 abstract "Evidence suggests that an unidentified mechanism associated with the S phase inhibition properties of 5-azacytidine may be just as or more important than its hypomethylating properties in eliciting gene expression. To determine how important the S phase properties of this agent are to the alteration of gene expression, I compared it with other S phase inhibitors which do not affect DNA methylation for their ability to derepress the hypoxanthine phosphoribosyl transferase gene on the inactive X chromosome. Of these agents, only 5-azacytidine was able to derepress this gene in CAK cells. It appears that 5-azacytidine does alter gene expression via DNA hypomethylation. The ability of other S phase inhibitors to increase fetal globin expression may be peculiar to this genetic system." @default.
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- W2054244025 date "1984-12-01" @default.
- W2054244025 modified "2023-09-25" @default.
- W2054244025 title "Comparison of the effectiveness of S phase inhibitors in altering gene expression" @default.
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- W2054244025 doi "https://doi.org/10.1016/0006-291x(84)90611-9" @default.
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