FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054258810> ?p ?o ?g. }

• W2054258810 endingPage "599" @default.
• W2054258810 startingPage "590" @default.
• W2054258810 abstract "Human papillomaviruses (HPV) have been associated with the development of non-melanoma skin cancer (NMSC) but the molecular mechanisms of the role of the virus in NMSC development are not clearly understood. Abnormal epithelial differentiation seen in malignant transformation of keratinocytes is associated with changes in keratin expression. The purpose of this study was to investigate the phenotype of primary human adult keratinocytes expressing early genes of HPV8 with specific reference to their differentiation and cell cycle profile to determine whether early genes of HPV8 lead to changes that are consistent with transformation. The expression of HPV8 early genes either individually or simultaneously caused distinct changes in the keratinocyte morphology and induced an abnormal keratin expression pattern, that included simple epithelial (K8, K18, K19), hyperproliferation-specific (K6, K16), basal-specific (K14, K15) and differentiation-specific (K1, K10) keratins. Our results indicate that expression of HPV8 early genes disrupts the normal keratin expression pattern in vitro. Expression of HPV8-E7 alone caused polyploidy that was associated with decreased expression of p21 and pRb. Expression of individual genes or in combination differentially influenced cell morphology and cell cycle distribution which might be important in HPV8-induced keratinocyte transformation." @default.
• W2054258810 created "2016-06-24" @default.
• W2054258810 creator A5001505568 @default.
• W2054258810 creator A5015713295 @default.
• W2054258810 creator A5045463371 @default.
• W2054258810 creator A5052408528 @default.
• W2054258810 creator A5084536128 @default.
• W2054258810 creator A5091531473 @default.
• W2054258810 date "2007-06-15" @default.
• W2054258810 modified "2023-10-17" @default.
• W2054258810 title "HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes" @default.
• W2054258810 cites W1557398645 @default.
• W2054258810 cites W1790478283 @default.
• W2054258810 cites W1818552086 @default.
• W2054258810 cites W1890532746 @default.
• W2054258810 cites W1969465898 @default.
• W2054258810 cites W1980182469 @default.
• W2054258810 cites W1984785242 @default.
• W2054258810 cites W1985384005 @default.
• W2054258810 cites W1990775155 @default.
• W2054258810 cites W1992982406 @default.
• W2054258810 cites W1994893503 @default.
• W2054258810 cites W1997469925 @default.
• W2054258810 cites W2001788009 @default.
• W2054258810 cites W2009697370 @default.
• W2054258810 cites W2016693266 @default.
• W2054258810 cites W2021925286 @default.
• W2054258810 cites W2025819392 @default.
• W2054258810 cites W2031504007 @default.
• W2054258810 cites W2033297572 @default.
• W2054258810 cites W2033867048 @default.
• W2054258810 cites W2035073821 @default.
• W2054258810 cites W2038013281 @default.
• W2054258810 cites W2039934202 @default.
• W2054258810 cites W2044556431 @default.
• W2054258810 cites W2047783594 @default.
• W2054258810 cites W2050105563 @default.
• W2054258810 cites W2050512563 @default.
• W2054258810 cites W2056349938 @default.
• W2054258810 cites W2063886817 @default.
• W2054258810 cites W2069810321 @default.
• W2054258810 cites W2082022486 @default.
• W2054258810 cites W2082873974 @default.
• W2054258810 cites W2083173659 @default.
• W2054258810 cites W2083883007 @default.
• W2054258810 cites W2087527298 @default.
• W2054258810 cites W2088724945 @default.
• W2054258810 cites W2089631233 @default.
• W2054258810 cites W2094904646 @default.
• W2054258810 cites W2098475608 @default.
• W2054258810 cites W2098765233 @default.
• W2054258810 cites W2108283430 @default.
• W2054258810 cites W2113290984 @default.
• W2054258810 cites W2113949653 @default.
• W2054258810 cites W2122314664 @default.
• W2054258810 cites W2128085834 @default.
• W2054258810 cites W2128443448 @default.
• W2054258810 cites W2130828047 @default.
• W2054258810 cites W2132014297 @default.
• W2054258810 cites W2141136534 @default.
• W2054258810 cites W2156891963 @default.
• W2054258810 cites W2160678012 @default.
• W2054258810 cites W2314951690 @default.
• W2054258810 cites W4250233718 @default.
• W2054258810 cites W4322701374 @default.
• W2054258810 doi "https://doi.org/10.1111/j.1600-0625.2007.00569.x" @default.
• W2054258810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423465" @default.
• W2054258810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17576239" @default.
• W2054258810 hasPublicationYear "2007" @default.
• W2054258810 type Work @default.
• W2054258810 sameAs 2054258810 @default.
• W2054258810 citedByCount "50" @default.
• W2054258810 countsByYear W20542588102012 @default.
• W2054258810 countsByYear W20542588102013 @default.
• W2054258810 countsByYear W20542588102014 @default.
• W2054258810 countsByYear W20542588102015 @default.
• W2054258810 countsByYear W20542588102016 @default.
• W2054258810 countsByYear W20542588102017 @default.
• W2054258810 countsByYear W20542588102019 @default.
• W2054258810 countsByYear W20542588102020 @default.
• W2054258810 countsByYear W20542588102021 @default.
• W2054258810 countsByYear W20542588102022 @default.
• W2054258810 crossrefType "journal-article" @default.
• W2054258810 hasAuthorship W2054258810A5001505568 @default.
• W2054258810 hasAuthorship W2054258810A5015713295 @default.
• W2054258810 hasAuthorship W2054258810A5045463371 @default.
• W2054258810 hasAuthorship W2054258810A5052408528 @default.
• W2054258810 hasAuthorship W2054258810A5084536128 @default.
• W2054258810 hasAuthorship W2054258810A5091531473 @default.
• W2054258810 hasBestOaLocation W20542588102 @default.
• W2054258810 hasConcept C102230213 @default.
• W2054258810 hasConcept C104317684 @default.
• W2054258810 hasConcept C127716648 @default.
• W2054258810 hasConcept C141035611 @default.
• W2054258810 hasConcept C148738053 @default.
• W2054258810 hasConcept C1491633281 @default.
• W2054258810 hasConcept C150194340 @default.
• W2054258810 hasConcept C170178370 @default.

• next