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- W2054265941 abstract "Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells. This review focuses on polyi:c-induced signaling pathways and the applications of polyi:c in cancer treatment." @default.
- W2054265941 created "2016-06-24" @default.
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- W2054265941 date "2010-12-15" @default.
- W2054265941 modified "2023-10-18" @default.
- W2054265941 title "Anticancer function of polyinosinic-polycytidylic acid" @default.
- W2054265941 doi "https://doi.org/10.4161/cbt.10.12.13450" @default.
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