Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054281644> ?p ?o ?g. }
- W2054281644 endingPage "7260" @default.
- W2054281644 startingPage "7251" @default.
- W2054281644 abstract "Fas ligand (FasL) is a 40-kDa type II transmembrane protein belonging to the tumor necrosis factor (TNF) family of proteins and binds to its specific receptor, Fas, a member of the TNF receptor family. Membrane-bound FasL can be processed into a soluble form by a metalloprotease similar to that which cleaves TNFα. Elevated levels of FasL have been implicated in a wide variety of diseases ranging from cancer to inflammatory abnormalities, which could be targeted by antibody therapy. We generated a fully human high-affinity antibody against FasL that binds to and neutralizes the activity of both soluble and membrane-associated human FasL. In order to elucidate the mechanism of function of this antibody, we have mapped the region and critical residues involved in the recognition of FasL using a combination of homology modeling, immunoprecipitation, hydrogen−deuterium exchange mass spectrometry (H/DXMS), and alanine scanning site-directed mutagenesis. These studies have revealed the antibody binding site on human FasL. Furthermore, through molecular homology modeling, we have proposed a mechanism for the neutralizing activity of this antibody that involves interference with the docking of the ligand to its receptor by the antibody." @default.
- W2054281644 created "2016-06-24" @default.
- W2054281644 creator A5006509459 @default.
- W2054281644 creator A5037553546 @default.
- W2054281644 creator A5058790752 @default.
- W2054281644 creator A5075074986 @default.
- W2054281644 creator A5083311199 @default.
- W2054281644 creator A5088857878 @default.
- W2054281644 date "2009-07-09" @default.
- W2054281644 modified "2023-09-25" @default.
- W2054281644 title "Determination of the Mechanism of Action of Anti-FasL Antibody by Epitope Mapping and Homology Modeling" @default.
- W2054281644 cites W105127712 @default.
- W2054281644 cites W1594653361 @default.
- W2054281644 cites W1642763135 @default.
- W2054281644 cites W1667210186 @default.
- W2054281644 cites W1838640007 @default.
- W2054281644 cites W1966700067 @default.
- W2054281644 cites W1976399964 @default.
- W2054281644 cites W1994516226 @default.
- W2054281644 cites W2002503549 @default.
- W2054281644 cites W2002507218 @default.
- W2054281644 cites W2015401858 @default.
- W2054281644 cites W2015652703 @default.
- W2054281644 cites W2016198585 @default.
- W2054281644 cites W2019802642 @default.
- W2054281644 cites W2027456984 @default.
- W2054281644 cites W2029593537 @default.
- W2054281644 cites W2036823751 @default.
- W2054281644 cites W2038221922 @default.
- W2054281644 cites W2045796964 @default.
- W2054281644 cites W2048023847 @default.
- W2054281644 cites W2062784484 @default.
- W2054281644 cites W2076656122 @default.
- W2054281644 cites W2078366306 @default.
- W2054281644 cites W2081253563 @default.
- W2054281644 cites W2106327084 @default.
- W2054281644 cites W2107452159 @default.
- W2054281644 cites W2108743612 @default.
- W2054281644 cites W2114078851 @default.
- W2054281644 cites W2118821335 @default.
- W2054281644 cites W2123575047 @default.
- W2054281644 cites W2132635116 @default.
- W2054281644 cites W2137296011 @default.
- W2054281644 cites W2143996326 @default.
- W2054281644 cites W2151630650 @default.
- W2054281644 cites W2157783216 @default.
- W2054281644 cites W2161458210 @default.
- W2054281644 cites W2164802863 @default.
- W2054281644 cites W2168747001 @default.
- W2054281644 cites W2227001432 @default.
- W2054281644 doi "https://doi.org/10.1021/bi900296g" @default.
- W2054281644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19588926" @default.
- W2054281644 hasPublicationYear "2009" @default.
- W2054281644 type Work @default.
- W2054281644 sameAs 2054281644 @default.
- W2054281644 citedByCount "24" @default.
- W2054281644 countsByYear W20542816442012 @default.
- W2054281644 countsByYear W20542816442013 @default.
- W2054281644 countsByYear W20542816442014 @default.
- W2054281644 countsByYear W20542816442015 @default.
- W2054281644 countsByYear W20542816442016 @default.
- W2054281644 countsByYear W20542816442021 @default.
- W2054281644 countsByYear W20542816442022 @default.
- W2054281644 crossrefType "journal-article" @default.
- W2054281644 hasAuthorship W2054281644A5006509459 @default.
- W2054281644 hasAuthorship W2054281644A5037553546 @default.
- W2054281644 hasAuthorship W2054281644A5058790752 @default.
- W2054281644 hasAuthorship W2054281644A5075074986 @default.
- W2054281644 hasAuthorship W2054281644A5083311199 @default.
- W2054281644 hasAuthorship W2054281644A5088857878 @default.
- W2054281644 hasConcept C104317684 @default.
- W2054281644 hasConcept C153911025 @default.
- W2054281644 hasConcept C159654299 @default.
- W2054281644 hasConcept C16318435 @default.
- W2054281644 hasConcept C169627665 @default.
- W2054281644 hasConcept C170493617 @default.
- W2054281644 hasConcept C17991360 @default.
- W2054281644 hasConcept C181199279 @default.
- W2054281644 hasConcept C185592680 @default.
- W2054281644 hasConcept C190283241 @default.
- W2054281644 hasConcept C195616568 @default.
- W2054281644 hasConcept C203014093 @default.
- W2054281644 hasConcept C24530287 @default.
- W2054281644 hasConcept C2780227090 @default.
- W2054281644 hasConcept C2781241564 @default.
- W2054281644 hasConcept C31573885 @default.
- W2054281644 hasConcept C501734568 @default.
- W2054281644 hasConcept C55493867 @default.
- W2054281644 hasConcept C66008609 @default.
- W2054281644 hasConcept C71829478 @default.
- W2054281644 hasConcept C86803240 @default.
- W2054281644 hasConceptScore W2054281644C104317684 @default.
- W2054281644 hasConceptScore W2054281644C153911025 @default.
- W2054281644 hasConceptScore W2054281644C159654299 @default.
- W2054281644 hasConceptScore W2054281644C16318435 @default.
- W2054281644 hasConceptScore W2054281644C169627665 @default.
- W2054281644 hasConceptScore W2054281644C170493617 @default.
- W2054281644 hasConceptScore W2054281644C17991360 @default.