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• W2054283723 abstract "The aloe vera plant has a long history of safe use for oral and topical applications. This publication describes safety studies conducted on a proprietary high-purity aloe vera inner leaf fillet preparation, Qmatrix®. In a 13-week study in rats, Qmatrix® was administered via gavage at 0, 500, 1000 and 2000 mg/kg body weight (bw)/day. There were no significant changes in food or water consumption, body weight, serum biochemistry or hematology at any of the doses tested. Sporadic, significant increases were observed in some of the measured urinalysis parameters; however, these variations were not treatment-related, as most were observed only in one sex, not dose-dependent and within historical control values. Organ weights were unaffected, except for a statistically significant, though not dose-dependent, increase in absolute and relative weights of the right kidney in males at 500 and 2000 mg/kg bw/day, respectively. Histopathological analysis revealed no abnormal signs. Qmatrix® was non-mutagenic in an Ames test and a chromosomal aberration test at concentrations up to 10,000 μg/plate, and in an in vivo bone marrow micronucleus test at doses up to 5000 mg/kg bw/day. Based on these results, Qmatrix® is not genotoxic in vitro or in vivo and; has an oral NOAEL greater than 2000 mg/kg bw/day following 90 days of oral exposure." @default.
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• W2054283723 date "2010-06-01" @default.
• W2054283723 modified "2023-10-16" @default.
• W2054283723 title "Safety studies conducted on a proprietary high-purity aloe vera inner leaf fillet preparation, Qmatrix®" @default.
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• W2054283723 doi "https://doi.org/10.1016/j.yrtph.2010.01.002" @default.
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