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• W2054288787 abstract "Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as jambolão in Brazil is widely used in folk medicine against leishmaniasis, inflammation, chronic diarrhea, and ulcers. It is one of the most commonly used plants for the treatment of diabetes worldwide. In previous studies, Syzygium cumini was shown to possess antihyperlipidemic and anti-allergic properties, and to exhibit good performance as an antimicrobial agent against bacteria, fungi, and protozoa parasites of the genus Leishmania and Trypanosoma. This study was aimed at evaluating the effects of S. cumini essential oil (ScEO) and its major component α-pinene on Leishmania (Leishmania) amazonensis, as well as their cytotoxicity and possible mechanisms of action.To evaluate the anti-proliferative effect on Leishmania, effects on promastigote and axenic amastigote forms were assessed using tetrazolium salt (MTT) assay. The intramacrophagic amastigotes were exposed to ScEO and α-pinene to determine the survival index. To gain insight into the mechanism of action involved in the effect on the samples, we evaluated the modulation of macrophage activation state by observing structural (phagocytic and lysosomal activities) and cellular (nitric oxide increase) changes. To assess the safety profile of ScEO and α-pinene, murine macrophages and human red blood cells were treated with ScEO and α-pinene and the selectivity index was calculated for each treatment.α-Pinene was effective against Leishmania amazonensis promastigote forms, with a half-maximal inhibitory concentration (IC50) value of 19.7µg/mL. α-Pinene was more active (IC50 values of 16.1 and 15.6µg/mL against axenic and intracellular amastigotes, respectively) than ScEO (IC50 values of 43.9 and 38.1µg/mL against axenic and intracellular amastigotes, respectively). Our results showed that the anti-Leishmania effects were mediated by immunomodulatory activity, as evidenced by the observed increases in both phagocytic and lysosomal activity, and the elevated NO levels. ScEO and α-pinene exhibited low cytotoxicity against murine macrophages and human erythrocytes. The 50% cytotoxicity concentration (CC50) values for the macrophages in the MTT assay were 614.1 and 425.2µg/mL for ScEO and α-pinene, respectively, while the corresponding half-maximal hemolytic concentration (HC50) values were 874.3 and 233.3µg/mL.Taken together, the results demonstrate that ScEO and its major constituent α-pinene have significant anti-Leishmania activity, modulated by macrophage activation, with acceptable levels of cytotoxicity in murine macrophages and human erythrocytes. Further work is warranted, involving more in-depth mechanistic studies and in vivo investigations." @default.
• W2054288787 created "2016-06-24" @default.
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• W2054288787 date "2015-02-01" @default.
• W2054288787 modified "2023-10-18" @default.
• W2054288787 title "Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro" @default.
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• W2054288787 cites W1964308028 @default.
• W2054288787 cites W1967197831 @default.
• W2054288787 cites W1969308892 @default.
• W2054288787 cites W1973162807 @default.
• W2054288787 cites W1973384531 @default.
• W2054288787 cites W1974828967 @default.
• W2054288787 cites W1976287687 @default.
• W2054288787 cites W1982360364 @default.
• W2054288787 cites W1992286852 @default.
• W2054288787 cites W1994744656 @default.
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• W2054288787 cites W2007513019 @default.
• W2054288787 cites W2013244526 @default.
• W2054288787 cites W2015929678 @default.
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• W2054288787 cites W2024621871 @default.
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• W2054288787 cites W2034371867 @default.
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• W2054288787 cites W2038093057 @default.
• W2054288787 cites W2039215936 @default.
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• W2054288787 cites W2044718313 @default.
• W2054288787 cites W2046144222 @default.
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• W2054288787 cites W2067134863 @default.
• W2054288787 cites W2073276898 @default.
• W2054288787 cites W2074802228 @default.
• W2054288787 cites W2078313196 @default.
• W2054288787 cites W2078676120 @default.
• W2054288787 cites W2086202349 @default.
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• W2054288787 doi "https://doi.org/10.1016/j.jep.2014.11.024" @default.
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