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• W2054289023 startingPage "130" @default.
• W2054289023 abstract "Allyl isothiocyanate (AITC), an organosulfur compound in cruciferous vegetables, is a natural antimicrobial and potential chemopreventive agent. However, the instability of AITC in aqueous systems restrains its applications. In this study, oil-in-water AITC nanoemulsion was prepared by the emulsion inversion point (EIP) method, aiming at improving the aqueous stability of AITC. The optimal hydrophilic–lipophilic balance (HLBop) value of surfactants containing Tween 80 and Span 80 was established at 11.0–13.0, yielding nanodroplets with diameters of 137–215 nm. The mechanism of droplet formation within the HLPop region was discussed in terms of the possible structure of adsorbed surfactant layers at the oil–water interface in multiple emulsion droplets. In a 6.5-month storage test, the droplet sizes and the count rates (intensity of scattered light) of nanoemulsions decreased only slightly by 4–13% (depending on surfactant-to-oil ratio), even in highly diluted status, indicating the desirable stability of the nanoemulsions. Moreover, the nanoemulsion demonstrated superior protection against AITC degradation (78% remaining after 60 d at 30 °C), compared with protein nanoparticles as well as non-encapsulated aqueous dispersion. This work shows for the first time that AITC can be formulated into nanoemulsions and thus obtains satisfactory aqueous solubility and chemical stability." @default.
• W2054289023 created "2016-06-24" @default.
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• W2054289023 date "2015-01-01" @default.
• W2054289023 modified "2023-10-14" @default.
• W2054289023 title "Enhancement of aqueous stability of allyl isothiocyanate using nanoemulsions prepared by an emulsion inversion point method" @default.
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• W2054289023 doi "https://doi.org/10.1016/j.jcis.2014.09.055" @default.
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