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• W2054292797 abstract "Abstract The intracerebroventricular injection of acetylcholine, carbachol and physostigmine induced hyperthermia in rabbits while muscarinic agents, pilocarpine and oxotremorine produce a biphasic thermal response consisting of an immediate hyperthermia followed by a delayed hypothermia. An involvement of central nicotinic receptors in the acetylcholine-induced hyperthermia is suggested, since it is blocked by intracerebroventricular pretreatment with chlorisondamine and (+)-tubocurarine and not by atropinization. On the other hand, stimulation of central muscarinic receptors in the hypothalamus are concerned in the delayed hypothermia induced by pilocarpine as it is blocked by prior central atropinization. Intracerebroventricular injection of catecholamines, viz. noradrenaline, adrenaline and dopamine, results in a hyperthermic response due to activation of α-adrenoceptors in the hypothalamus, since norepinephrine hyperthermia is blocked by intracerebroventricular pretreatment with phenoxybenzamine and not by propranolol. Furthermore, a blockade of norepinephrine hyperthermia by pretreatment with chlorisondamine and not by prior atropinization suggests that the activation of central α-adrenoceptors in turn stimulates the cholinergic system which is nicotinic in nature. On the contrary, intracerebroventricular 5-hydroxytryptophan and 5-hydroxytryptamine caused hypothermia which is due to an activation of central muscarinic receptors since it is found to be blocked by prior intracerebroventricular administration of ethybenztropine and not by chlorisondamine pretreatment. On the basis of these observations, an interaction between adrenergic and nicotinic mechanisms as well as between tryptaminergic and muscarinic systems is suggested in the hypothalamic thermoregulation in rabbits for the hyperthermic and hypothermie responses, respectively." @default.
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• W2054292797 date "1974-05-01" @default.
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• W2054292797 title "Interrelation between monoaminergic and cholinergic mechanisms in the hypothalamic thermoregulatory centre of rabbits" @default.
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• W2054292797 doi "https://doi.org/10.1016/0028-3908(74)90116-6" @default.
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