Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054293840> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2054293840 endingPage "287" @default.
- W2054293840 startingPage "281" @default.
- W2054293840 abstract "The neurologic mutant “dilute lethal” (dl) mice, which reveal several neurologic and biochemical disturbances similar to human phenylketonuria, were used to investigate some aspects of amino acid disorder. We have studied the free amino pool in the brain of “dl” mice and of their control littermates as well as phenylalanine and tyrosine levels in brain and liver as a function of age and after phenylalamine overload. The tyrosine level decreased in brain and liver of affected mice whereas the phenylalanine/tyrosine ratio increased as a function of age. The significantly higher phenylalanine level and phenylalanine/tyrosine ratio in the liver of 20-day-old “dl” mice suggest a lower liver phenylalanine hydroxylase activity. After phenylalanine overload, the impairment of phenylalanine metabolism is predominant in the brain of “dl” mice, suggesting a disturbance in phenylalanine hydroxylation. A decrease in the level of several amino acids occurs in the brains of “dl” mice without or after phenylalanine overload; these facts might correspond to a disturbance in the transfer of amino acids to the brain and may lead to impairment in protein synthesis." @default.
- W2054293840 created "2016-06-24" @default.
- W2054293840 creator A5032012805 @default.
- W2054293840 creator A5055586404 @default.
- W2054293840 creator A5058917154 @default.
- W2054293840 creator A5067277960 @default.
- W2054293840 creator A5086029815 @default.
- W2054293840 date "1977-01-01" @default.
- W2054293840 modified "2023-09-25" @default.
- W2054293840 title "Free amino acid pool in the brain of mice homozygous for the gene ?dilute lethal?" @default.
- W2054293840 cites W1583099451 @default.
- W2054293840 cites W168896472 @default.
- W2054293840 cites W1951885578 @default.
- W2054293840 cites W1969450110 @default.
- W2054293840 cites W1973353186 @default.
- W2054293840 cites W1981229103 @default.
- W2054293840 cites W2034910577 @default.
- W2054293840 cites W2048729999 @default.
- W2054293840 cites W2051259433 @default.
- W2054293840 cites W2051352196 @default.
- W2054293840 cites W2062094657 @default.
- W2054293840 cites W2063471775 @default.
- W2054293840 cites W2067057701 @default.
- W2054293840 cites W2069967922 @default.
- W2054293840 cites W2084345211 @default.
- W2054293840 cites W2086723807 @default.
- W2054293840 doi "https://doi.org/10.1002/jnr.490030406" @default.
- W2054293840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/566796" @default.
- W2054293840 hasPublicationYear "1977" @default.
- W2054293840 type Work @default.
- W2054293840 sameAs 2054293840 @default.
- W2054293840 citedByCount "2" @default.
- W2054293840 crossrefType "journal-article" @default.
- W2054293840 hasAuthorship W2054293840A5032012805 @default.
- W2054293840 hasAuthorship W2054293840A5055586404 @default.
- W2054293840 hasAuthorship W2054293840A5058917154 @default.
- W2054293840 hasAuthorship W2054293840A5067277960 @default.
- W2054293840 hasAuthorship W2054293840A5086029815 @default.
- W2054293840 hasConcept C126322002 @default.
- W2054293840 hasConcept C134018914 @default.
- W2054293840 hasConcept C185592680 @default.
- W2054293840 hasConcept C207009774 @default.
- W2054293840 hasConcept C2776165026 @default.
- W2054293840 hasConcept C2777431362 @default.
- W2054293840 hasConcept C2777992278 @default.
- W2054293840 hasConcept C515207424 @default.
- W2054293840 hasConcept C55493867 @default.
- W2054293840 hasConcept C62231903 @default.
- W2054293840 hasConcept C71924100 @default.
- W2054293840 hasConcept C86803240 @default.
- W2054293840 hasConceptScore W2054293840C126322002 @default.
- W2054293840 hasConceptScore W2054293840C134018914 @default.
- W2054293840 hasConceptScore W2054293840C185592680 @default.
- W2054293840 hasConceptScore W2054293840C207009774 @default.
- W2054293840 hasConceptScore W2054293840C2776165026 @default.
- W2054293840 hasConceptScore W2054293840C2777431362 @default.
- W2054293840 hasConceptScore W2054293840C2777992278 @default.
- W2054293840 hasConceptScore W2054293840C515207424 @default.
- W2054293840 hasConceptScore W2054293840C55493867 @default.
- W2054293840 hasConceptScore W2054293840C62231903 @default.
- W2054293840 hasConceptScore W2054293840C71924100 @default.
- W2054293840 hasConceptScore W2054293840C86803240 @default.
- W2054293840 hasIssue "4" @default.
- W2054293840 hasLocation W20542938401 @default.
- W2054293840 hasLocation W20542938402 @default.
- W2054293840 hasOpenAccess W2054293840 @default.
- W2054293840 hasPrimaryLocation W20542938401 @default.
- W2054293840 hasRelatedWork W2020061999 @default.
- W2054293840 hasRelatedWork W2054293840 @default.
- W2054293840 hasRelatedWork W2066530401 @default.
- W2054293840 hasRelatedWork W2087325908 @default.
- W2054293840 hasRelatedWork W2099121494 @default.
- W2054293840 hasRelatedWork W2163959508 @default.
- W2054293840 hasRelatedWork W283401092 @default.
- W2054293840 hasRelatedWork W4210983804 @default.
- W2054293840 hasRelatedWork W4239812013 @default.
- W2054293840 hasRelatedWork W848914235 @default.
- W2054293840 hasVolume "3" @default.
- W2054293840 isParatext "false" @default.
- W2054293840 isRetracted "false" @default.
- W2054293840 magId "2054293840" @default.
- W2054293840 workType "article" @default.