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• W2054293889 startingPage "2585" @default.
• W2054293889 abstract "Highly active antiretroviral therapy (HAART) has vastly improved outcomes for patients infected with HIV, yet it is a lifelong regimen that is expensive and has significant side effects. Retroviral gene therapy is a promising alternative treatment for HIV/AIDS; however, inefficient gene delivery to hematopoietic stem cells (HSCs) has so far limited the efficacy of this approach. Foamy virus (FV) vectors are derived from non-pathogenic viruses that are not endemic to the human population. FV vectors have been used to deliver HIV-inhibiting transgenes to human HSCs, and they have several advantages relative to other retroviral vectors. These include an attractive safety profile, broad tropism, a large transgene capacity, and the ability to persist in quiescent cells. In addition, the titers of FV vectors are not reduced by anti-HIV transgenes that affect the production of lentivirus (LV) vectors. Thus FV vectors are very promising for anti-HIV gene therapy. This review covers the advantages of FV vectors and describes their preclinical development for anti-HIV gene therapy." @default.
• W2054293889 created "2016-06-24" @default.
• W2054293889 creator A5042014664 @default.
• W2054293889 creator A5065033882 @default.
• W2054293889 date "2013-10-22" @default.
• W2054293889 modified "2023-10-05" @default.
• W2054293889 title "Foamy Virus Vectors for HIV Gene Therapy" @default.
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• W2054293889 doi "https://doi.org/10.3390/v5102585" @default.
• W2054293889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814606" @default.
• W2054293889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24153061" @default.
• W2054293889 hasPublicationYear "2013" @default.
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