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• W2054293890 abstract "The paper explores the future of (clinical) biostatistics. In the first part of the paper important trends in biostatistics are reviewed: new applications and more complex data; causal models for observational data; cross-validation-based model building; graphical chain and random effect models; faster computing and new algorithms as Markov chain Monte Carlo; generalized estimating equations and pseudo-likelihood; pooled data sets for meta-analysis and prognostic modelling. In the second part some dreams and nightmares of the author are sketched. Dreams are: implementation of prognostic and diagnostic models in the clinic; an instantaneous numeric integrator; much more and better organized follow-up data; disease mapping in space and time. ‘Nightmares’, that is, issues which it is hoped will go out of use in the future, are: P-value; rank tests; exact methods; meta-analysis; matched case-control studies. © 1997 John Wiley & Sons, Ltd." @default.
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• W2054293890 date "1997-12-30" @default.
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• W2054293890 title "The future of biostatistics: expecting the unexpected" @default.
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• W2054293890 doi "https://doi.org/10.1002/(sici)1097-0258(19971230)16:24<2773::aid-sim761>3.0.co;2-q" @default.
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