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• W2054294502 abstract "Summary The distribution and dynamic changes of CD 4 + CD 25 + F ox P 3 + and CD 4 + CD 25 − F ox P 3 + regulatory T (Treg) cells induced by human rotavirus ( HRV ) infection and vaccination were examined in neonatal gnotobiotic pigs infected with virulent HRV (Vir HRV ) or vaccinated with attenuated HRV (Att HRV ). Subsets of gnotobiotic pigs in the Att HRV and control groups were challenged with Vir HRV at post‐inoculation day ( PID ) 28. We demonstrated that Vir HRV infection or Att HRV vaccination reduced frequencies and numbers of tissue‐residing Treg cells, and decreased the frequencies of interleukin‐10 ( IL ‐10) and transforming growth factor‐β ( TGF ‐β) producing CD 4 + CD 25 − Treg cells in ileum, spleen and blood at PID 28. The frequencies of IL ‐10 and TGF ‐β producing CD 4 + CD 25 − Treg cells in all sites at PID 28 were significantly inversely correlated with the protection rate against Vir HRV ‐caused diarrhoea ( r = −1, P < 0·0001). Hence, higher frequencies of functional CD 4 + CD 25 − Treg cells can be an indicator for poorer protective immunity against rotavirus. Our results highlighted the importance of CD 4 + CD 25 − Treg cells over CD 4 + CD 25 + Treg cells in rotavirus infection and immunity. Att HRV vaccination (induction of immune effector responses) reduced the expansion of CD 4 + CD 25 − Treg cells in ileum seen in the challenged naive pigs during the acute phase of Vir HRV infection and preserved normal levels of intestinal TGF ‐β producing Treg cells post‐challenge. The reduced suppressive effect of Treg cells in Att HRV ‐vaccinated pigs would unleash effector/memory T ‐cell activation upon challenge. Preserving TGF ‐β producing CD 4 + CD 25 − Treg cells is important in maintaining homeostasis. Based on our findings, a model is proposed to depict the dynamic equilibrium course of Treg and effector T ‐cell responses after primary rotavirus infection/vaccination and challenge." @default.
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• W2054294502 date "2012-09-04" @default.
• W2054294502 modified "2023-10-12" @default.
• W2054294502 title "CD4+ CD25− FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs" @default.
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• W2054294502 doi "https://doi.org/10.1111/j.1365-2567.2012.03617.x" @default.
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