FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054296979> ?p ?o ?g. }

• W2054296979 endingPage "283" @default.
• W2054296979 startingPage "277" @default.
• W2054296979 abstract "We have characterized the tachykinin NK(2) receptor-mediated contraction and vectorial ion transport responses in the muscularis mucosae and mucosa of the rat isolated distal colon, respectively. The tachykinin NK(2) receptor-selective antagonist nepadutant (c([(beta-D-GlcNAc)Asn-Asp-Trp-Phe-Dpr-Leu]c(2beta-5beta))) produced competitive antagonism of [betaAla(8)]neurokinin A-(4-10)-induced contraction (pK(B) = 9.3) in the muscularis mucosae, and insurmountable blockade of increases in short-circuit current (I(sc)) responses (pK(B) = 8.6) in the mucosa. However, this latter effect was completely reversed by washout of the antagonist. [betaAla(8)]Neurokinin A-(4-10)-induced contractions were unaffected by indomethacin (3 microM). In sharp contrast, I(sc) responses induced by [betaAla(8)]neurokinin A-(4-10) (100 nM) were inhibited (>70%) by indomethacin (3 microM), while I(sc) responses to substance P (3 microM) were unchanged. Our study provides the first evidence that in the same organ stimulation of tachykinin NK(2) receptors leads to two independent responses mediated by different effector mechanisms both of which are blocked (albeit with different kinetics) by the potent and selective tachykinin NK(2) receptor antagonist, nepadutant." @default.
• W2054296979 created "2016-06-24" @default.
• W2054296979 creator A5007685909 @default.
• W2054296979 creator A5032585100 @default.
• W2054296979 creator A5044900901 @default.
• W2054296979 creator A5079964496 @default.
• W2054296979 creator A5089436979 @default.
• W2054296979 date "2001-03-01" @default.
• W2054296979 modified "2023-10-13" @default.
• W2054296979 title "Tachykinin NK2 receptor mediates contraction and ion transport in rat colon by different mechanisms" @default.
• W2054296979 cites W1540911990 @default.
• W2054296979 cites W1967099995 @default.
• W2054296979 cites W1972312867 @default.
• W2054296979 cites W1978210078 @default.
• W2054296979 cites W1980875837 @default.
• W2054296979 cites W1980951772 @default.
• W2054296979 cites W1984030173 @default.
• W2054296979 cites W1985580976 @default.
• W2054296979 cites W1998005894 @default.
• W2054296979 cites W2001155177 @default.
• W2054296979 cites W2002082552 @default.
• W2054296979 cites W2009184686 @default.
• W2054296979 cites W2021226471 @default.
• W2054296979 cites W2024372998 @default.
• W2054296979 cites W2031696854 @default.
• W2054296979 cites W2041276471 @default.
• W2054296979 cites W2046007618 @default.
• W2054296979 cites W2057971042 @default.
• W2054296979 cites W2075356407 @default.
• W2054296979 cites W2087076633 @default.
• W2054296979 cites W2104294303 @default.
• W2054296979 cites W2119278901 @default.
• W2054296979 cites W2135019312 @default.
• W2054296979 cites W2146390263 @default.
• W2054296979 cites W2152250095 @default.
• W2054296979 cites W2414813073 @default.
• W2054296979 doi "https://doi.org/10.1016/s0014-2999(01)00836-6" @default.
• W2054296979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275010" @default.
• W2054296979 hasPublicationYear "2001" @default.
• W2054296979 type Work @default.
• W2054296979 sameAs 2054296979 @default.
• W2054296979 citedByCount "11" @default.
• W2054296979 crossrefType "journal-article" @default.
• W2054296979 hasAuthorship W2054296979A5007685909 @default.
• W2054296979 hasAuthorship W2054296979A5032585100 @default.
• W2054296979 hasAuthorship W2054296979A5044900901 @default.
• W2054296979 hasAuthorship W2054296979A5079964496 @default.
• W2054296979 hasAuthorship W2054296979A5089436979 @default.
• W2054296979 hasConcept C118303440 @default.
• W2054296979 hasConcept C126322002 @default.
• W2054296979 hasConcept C134018914 @default.
• W2054296979 hasConcept C163415756 @default.
• W2054296979 hasConcept C170493617 @default.
• W2054296979 hasConcept C185592680 @default.
• W2054296979 hasConcept C24998067 @default.
• W2054296979 hasConcept C2776533618 @default.
• W2054296979 hasConcept C2776885963 @default.
• W2054296979 hasConcept C2777056410 @default.
• W2054296979 hasConcept C2777383412 @default.
• W2054296979 hasConcept C2777960253 @default.
• W2054296979 hasConcept C2778122271 @default.
• W2054296979 hasConcept C55938493 @default.
• W2054296979 hasConcept C71924100 @default.
• W2054296979 hasConcept C86803240 @default.
• W2054296979 hasConceptScore W2054296979C118303440 @default.
• W2054296979 hasConceptScore W2054296979C126322002 @default.
• W2054296979 hasConceptScore W2054296979C134018914 @default.
• W2054296979 hasConceptScore W2054296979C163415756 @default.
• W2054296979 hasConceptScore W2054296979C170493617 @default.
• W2054296979 hasConceptScore W2054296979C185592680 @default.
• W2054296979 hasConceptScore W2054296979C24998067 @default.
• W2054296979 hasConceptScore W2054296979C2776533618 @default.
• W2054296979 hasConceptScore W2054296979C2776885963 @default.
• W2054296979 hasConceptScore W2054296979C2777056410 @default.
• W2054296979 hasConceptScore W2054296979C2777383412 @default.
• W2054296979 hasConceptScore W2054296979C2777960253 @default.
• W2054296979 hasConceptScore W2054296979C2778122271 @default.
• W2054296979 hasConceptScore W2054296979C55938493 @default.
• W2054296979 hasConceptScore W2054296979C71924100 @default.
• W2054296979 hasConceptScore W2054296979C86803240 @default.
• W2054296979 hasIssue "2-3" @default.
• W2054296979 hasLocation W20542969791 @default.
• W2054296979 hasLocation W20542969792 @default.
• W2054296979 hasOpenAccess W2054296979 @default.
• W2054296979 hasPrimaryLocation W20542969791 @default.
• W2054296979 hasRelatedWork W1991782556 @default.
• W2054296979 hasRelatedWork W2012185263 @default.
• W2054296979 hasRelatedWork W2044837801 @default.
• W2054296979 hasRelatedWork W2072692041 @default.
• W2054296979 hasRelatedWork W2093837047 @default.
• W2054296979 hasRelatedWork W2150393025 @default.
• W2054296979 hasRelatedWork W2231873071 @default.
• W2054296979 hasRelatedWork W2471848544 @default.
• W2054296979 hasRelatedWork W35259421 @default.
• W2054296979 hasRelatedWork W4232664641 @default.
• W2054296979 hasVolume "415" @default.
• W2054296979 isParatext "false" @default.
• W2054296979 isRetracted "false" @default.

• next