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• W2054300567 abstract "No AccessJournal of UrologyInvestigative urology1 Feb 2007Expression of Major Heat Shock Proteins in Prostate Cancer: Correlation With Clinicopathological Outcomes in Patients Undergoing Radical Prostatectomyis companion ofVariation in the Definition of Biochemical Recurrence in Patients Treated for Localized Prostate Cancer: The American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel Report and Recommendations for a Standard in the Reporting of Surgical Outcomes Toshifumi Kurahashi, Hideaki Miyake, Isao Hara, and Masato Fujisawa Toshifumi KurahashiToshifumi Kurahashi More articles by this author , Hideaki MiyakeHideaki Miyake More articles by this author , Isao HaraIsao Hara More articles by this author , and Masato FujisawaMasato Fujisawa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.09.073AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated expression levels of major heat shock proteins in radical prostatectomy specimens to clarify the significance of heat shock protein expression in prostate cancer. Materials and Methods: Expression levels of heat shock proteins 27, 70 and 90 in radical prostatectomy specimens from 172 patients with clinically organ confined prostate cancer who had not received neoadjuvant hormonal therapy were measured by immunohistochemical staining. Cell proliferative activities and apoptotic features in these specimens were investigated using Ki-67 immunostaining and TUNEL assay, respectively. These findings were analyzed with respect to several clinicopathological factors. Results: Various levels of heat shock protein 27 expression were noted in all prostate cancer specimens. Expression levels of heat shock protein 27 in prostate cancer tissues was significantly associated with pathological stage, Gleason score, surgical margin status, lymph node metastasis and tumor volume but not with other parameters, including patient age, serum prostate specific antigen and perineural invasion. Similarly most prostate cancer tissues showed heat shock protein 70 and 90 expression. However, there was no significant correlation between expression levels of these 2 heat shock proteins and several clinicopathological factors examined. Cell proliferative activity in prostate cancer specimens was significantly associated with heat shock protein 27 expression but not with that of heat shock proteins 70 and 90, while there was no significant correlation between the apoptotic index and the expression of these 3 heat shock proteins. Furthermore, despite the lack of prognostic significance in heat shock proteins 70 and 90 expression, biochemical recurrence-free survival in patients with strong heat shock protein 27 expression in radical prostatectomy specimens was significantly lower than that in those with weak heat shock protein 27 expression. However, multivariate analysis showed that strong heat shock protein 27 expression could not be an independent predictor of biochemical recurrence after radical prostatectomy. Conclusions: These findings suggest that, despite the limited significance of heat shock proteins 70 and 90 expression, heat shock protein 27 may be involved in the progression of prostate cancer. The expression level of heat shock protein 27 in prostate cancer tissue could be used as a useful predictor of biochemical recurrence in patients undergoing radical prostatectomy. References 1 : Cells in stress: transcriptional activation of heat shock genes. Science1993; 259: 1409. Google Scholar 2 : Heat shock proteins: their role in urological tumors. J Urol2003; 169: 338. Link, Google Scholar 3 : Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene2005; 24: 3328. Google Scholar 4 : Escaping cell death: survival proteins in cancer. Exp Cell Res1999; 248: 30. Google Scholar 5 : Chaperons in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif2000; 92: 1564. Google Scholar 6 : Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res2004; 64: 6595. Google Scholar 7 : Detection and distribution of heat shock proteins 27 and 90 in human benign and malignant prostatic tissue. Br J Urol1996; 77: 367. Crossref, Medline, Google Scholar 8 : Heat-shock proteins inhibit induction of prostate cancer cell apoptosis. Prostate2000; 45: 58. Crossref, Medline, Google Scholar 9 : Heat shock protein expression independently predicts clinical outcome in prostate cancer. Cancer Res2000; 60: 7099. Medline, Google Scholar 10 : Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J Natl Cancer Inst1999; 91: 1758. Google Scholar 11 : Hsp90 as a therapeutic target in prostate cancer. Semin Oncol2003; 30: 709. Google Scholar 12 : Expression of the secreted form of clusterin protein in renal cell carcinoma as a predictor of disease extension. BJU Int2005; 96: 895. Google Scholar 13 Miyake H, Muramaki M, Kurahashi T, Yamanaka K, Hara I and Fujisawa M: Enhanced expression of heat shock protein 27 following neoadjuvant hormonal therapy is associated with poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer. Unpublished data. Google Scholar 14 : Percent carcinoma in prostatectomy specimens is associated with risk of recurrence after radical prostatectomy in patients with pathological organ confined prostate cancer. J Urol2004; 172: 137. Link, Google Scholar 15 : Biochemical failure in men following radical retropubic prostatectomy: impact of surgical margin status and location. J Urol2004; 172: 129. Link, Google Scholar 16 : Expression patterns of potential therapeutic targets in prostate cancer. Int J Cancer2005; 113: 619. Google Scholar Departments of Urology, Kobe University School of Medicine and Hara Genitourinary Hospital, Kobe and Hyogo Medical Center for Adults, Akashi, Japan© 2007 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology9 Nov 2018Variation in the Definition of Biochemical Recurrence in Patients Treated for Localized Prostate Cancer: The American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel Report and Recommendations for a Standard in the Reporting of Surgical Outcomes Volume 177Issue 2February 2007Page: 757-761 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordslocalprostatic neoplasmsprostateneoplasm recurrenceprostatectomyheat-shock proteinsMetricsAuthor Information Toshifumi Kurahashi More articles by this author Hideaki Miyake More articles by this author Isao Hara More articles by this author Masato Fujisawa More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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