FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054310642> ?p ?o ?g. }

• W2054310642 endingPage "12512" @default.
• W2054310642 startingPage "12498" @default.
• W2054310642 abstract "The antiviral and antiproliferative activities of human type I interferons (IFNs) are mediated by two transmembrane receptor subunits, IFNAR1 and IFNAR2. To elucidate the role of IFNAR1 in IFN binding and the establishment of biological activity, specific residues of IFNAR1 were mutated. Residues 62FSSLKLNVY70 of the S5−S6 loop of the N-terminal subdomain of IFNAR1 and tryptophan-129 of the second subdomain of IFNAR1 were shown to be crucial for IFN-α binding and signaling and establishment of biological activity. Mutagenesis of peptide 278LRV in the third subdomain shows that these residues are critical for IFN-α-induced biological activity but not for ligand binding. These data, together with the sequence homology of IFNAR1 with cytokine receptors of known structure and the recently resolved NMR structure of IFNAR2, led to the establishment of a three-dimensional model of the human IFN-α/IFNAR1/IFNAR2 complex. This model predicts that following binding of IFN to IFNAR1 and IFNAR2 the receptor complex assumes a “closed form”, in which the N-terminal domain of IFNAR1 acts as a lid, resulting in the activation of intracellular kinases. Differences in the primary sequence of individual IFN-α subtypes and resulting differences in binding affinity, duration of ligand/receptor association, or both would explain differences in intracellular signal intensities and biological activity observed for individual IFN-α subtypes." @default.
• W2054310642 created "2016-06-24" @default.
• W2054310642 creator A5021726119 @default.
• W2054310642 creator A5025126749 @default.
• W2054310642 creator A5026203276 @default.
• W2054310642 creator A5028689502 @default.
• W2054310642 creator A5029586636 @default.
• W2054310642 creator A5039869655 @default.
• W2054310642 creator A5065425295 @default.
• W2054310642 creator A5073428513 @default.
• W2054310642 creator A5077415280 @default.
• W2054310642 creator A5081955768 @default.
• W2054310642 date "2004-09-11" @default.
• W2054310642 modified "2023-10-06" @default.
• W2054310642 title "Identification of Residues of the IFNAR1 Chain of the Type I Human Interferon Receptor Critical for Ligand Binding and Biological Activity" @default.
• W2054310642 cites W1505071696 @default.
• W2054310642 cites W1544033113 @default.
• W2054310642 cites W1550642408 @default.
• W2054310642 cites W1554187319 @default.
• W2054310642 cites W1969342632 @default.
• W2054310642 cites W1987009823 @default.
• W2054310642 cites W2006061341 @default.
• W2054310642 cites W2006672434 @default.
• W2054310642 cites W2014743999 @default.
• W2054310642 cites W2021989879 @default.
• W2054310642 cites W2056358900 @default.
• W2054310642 cites W2065283382 @default.
• W2054310642 cites W2071442507 @default.
• W2054310642 cites W2071486470 @default.
• W2054310642 cites W2075256922 @default.
• W2054310642 cites W2078993960 @default.
• W2054310642 cites W2109397495 @default.
• W2054310642 cites W2122203471 @default.
• W2054310642 cites W2125106761 @default.
• W2054310642 cites W2157135427 @default.
• W2054310642 cites W2399467729 @default.
• W2054310642 cites W2615531293 @default.
• W2054310642 doi "https://doi.org/10.1021/bi049111r" @default.
• W2054310642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15449939" @default.
• W2054310642 hasPublicationYear "2004" @default.
• W2054310642 type Work @default.
• W2054310642 sameAs 2054310642 @default.
• W2054310642 citedByCount "33" @default.
• W2054310642 countsByYear W20543106422013 @default.
• W2054310642 countsByYear W20543106422014 @default.
• W2054310642 countsByYear W20543106422015 @default.
• W2054310642 countsByYear W20543106422016 @default.
• W2054310642 countsByYear W20543106422019 @default.
• W2054310642 countsByYear W20543106422020 @default.
• W2054310642 crossrefType "journal-article" @default.
• W2054310642 hasAuthorship W2054310642A5021726119 @default.
• W2054310642 hasAuthorship W2054310642A5025126749 @default.
• W2054310642 hasAuthorship W2054310642A5026203276 @default.
• W2054310642 hasAuthorship W2054310642A5028689502 @default.
• W2054310642 hasAuthorship W2054310642A5029586636 @default.
• W2054310642 hasAuthorship W2054310642A5039869655 @default.
• W2054310642 hasAuthorship W2054310642A5065425295 @default.
• W2054310642 hasAuthorship W2054310642A5073428513 @default.
• W2054310642 hasAuthorship W2054310642A5077415280 @default.
• W2054310642 hasAuthorship W2054310642A5081955768 @default.
• W2054310642 hasConcept C104317684 @default.
• W2054310642 hasConcept C107824862 @default.
• W2054310642 hasConcept C116073593 @default.
• W2054310642 hasConcept C116569031 @default.
• W2054310642 hasConcept C118892022 @default.
• W2054310642 hasConcept C16318435 @default.
• W2054310642 hasConcept C170493617 @default.
• W2054310642 hasConcept C185592680 @default.
• W2054310642 hasConcept C202751555 @default.
• W2054310642 hasConcept C24530287 @default.
• W2054310642 hasConcept C501734568 @default.
• W2054310642 hasConcept C55493867 @default.
• W2054310642 hasConcept C71240020 @default.
• W2054310642 hasConcept C79879829 @default.
• W2054310642 hasConcept C86803240 @default.
• W2054310642 hasConcept C95444343 @default.
• W2054310642 hasConceptScore W2054310642C104317684 @default.
• W2054310642 hasConceptScore W2054310642C107824862 @default.
• W2054310642 hasConceptScore W2054310642C116073593 @default.
• W2054310642 hasConceptScore W2054310642C116569031 @default.
• W2054310642 hasConceptScore W2054310642C118892022 @default.
• W2054310642 hasConceptScore W2054310642C16318435 @default.
• W2054310642 hasConceptScore W2054310642C170493617 @default.
• W2054310642 hasConceptScore W2054310642C185592680 @default.
• W2054310642 hasConceptScore W2054310642C202751555 @default.
• W2054310642 hasConceptScore W2054310642C24530287 @default.
• W2054310642 hasConceptScore W2054310642C501734568 @default.
• W2054310642 hasConceptScore W2054310642C55493867 @default.
• W2054310642 hasConceptScore W2054310642C71240020 @default.
• W2054310642 hasConceptScore W2054310642C79879829 @default.
• W2054310642 hasConceptScore W2054310642C86803240 @default.
• W2054310642 hasConceptScore W2054310642C95444343 @default.
• W2054310642 hasIssue "39" @default.
• W2054310642 hasLocation W20543106421 @default.
• W2054310642 hasLocation W20543106422 @default.
• W2054310642 hasOpenAccess W2054310642 @default.
• W2054310642 hasPrimaryLocation W20543106421 @default.
• W2054310642 hasRelatedWork W1540599686 @default.

• next