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• W2054313673 abstract "Explants from the retinal pigment epithelium and the underlying choroid and sclera were dissected from human eyes and transferred to culture wells. The mechanical trauma caused by the dissection and removal of the explants, and the changes in biological milieu caused by transfer of the tissue to an in vitro system causes injury, necrosis and detachment of cells from Bruch's membrane. In the retinal pigment epithelium, cells adjacent to damaged, spherical and detaching cells and smaller cell free zones from rosettes. At the periphery of big defects, the cells spread out to cover the denuded areas of Bruch's membrane. The present work has shown that cell injury in the human retinal pigment epithelium is followed by reactive cellular changes in vitro. The result of these reactive changes are increased variation in cellular form and magnitude and in pigment concentration per unit area." @default.
• W2054313673 created "2016-06-24" @default.
• W2054313673 creator A5002835539 @default.
• W2054313673 creator A5044054875 @default.
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• W2054313673 date "2009-05-27" @default.
• W2054313673 modified "2023-09-27" @default.
• W2054313673 title "REACTIVE CHANGES IN THE HUMAN RETINAL PIGMENT EPITHELIUM IN VITRO" @default.
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• W2054313673 doi "https://doi.org/10.1111/j.1755-3768.1981.tb08332.x" @default.
• W2054313673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7315205" @default.
• W2054313673 hasPublicationYear "2009" @default.
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