FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054319806> ?p ?o ?g. }

• W2054319806 endingPage "6857" @default.
• W2054319806 startingPage "6850" @default.
• W2054319806 abstract "The treatment of malignant glioma is currently ineffective. Oncolytic viruses are being explored as a means to selectively lyse tumor cells in the brain. We have engineered a mutant herpes simplex virus type 1 with deletions in the viral UL39 and gamma(1)34.5 genes and an insertion of the two prodrug activating genes, CYP2B1 and secreted human intestinal carboxylesterase. Each of these can convert the inactive prodrugs, cyclophosphamide and irinotecan (CPT-11), into their active metabolites, respectively. This new oncolytic virus (MGH2) displays increased antitumor efficacy against human glioma cells both in vitro and in vivo when combined with cyclophosphamide and CPT-11. Importantly, cyclophosphamide, CPT-11, or the combination of cyclophosphamide and CPT-11 does not significantly affect oncolytic virus replication. Therefore, MGH2 provides effective multimodal therapy for gliomas in preclinical models when combined with these chemotherapy agents." @default.
• W2054319806 created "2016-06-24" @default.
• W2054319806 creator A5003547110 @default.
• W2054319806 creator A5010422151 @default.
• W2054319806 creator A5032094946 @default.
• W2054319806 creator A5033917464 @default.
• W2054319806 creator A5058502526 @default.
• W2054319806 creator A5065678645 @default.
• W2054319806 creator A5076493366 @default.
• W2054319806 creator A5077387268 @default.
• W2054319806 creator A5078921760 @default.
• W2054319806 date "2005-08-01" @default.
• W2054319806 modified "2023-10-16" @default.
• W2054319806 title "Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, <i>CYP2B1</i> and <i>Secreted Human Intestinal Carboxylesterase</i>, in Combination with Cyclophosphamide and Irinotecan" @default.
• W2054319806 cites W1559374697 @default.
• W2054319806 cites W1584092960 @default.
• W2054319806 cites W1969099442 @default.
• W2054319806 cites W1969202313 @default.
• W2054319806 cites W1972840654 @default.
• W2054319806 cites W1987644026 @default.
• W2054319806 cites W1991069782 @default.
• W2054319806 cites W1992800374 @default.
• W2054319806 cites W2001786959 @default.
• W2054319806 cites W2004762154 @default.
• W2054319806 cites W2036589843 @default.
• W2054319806 cites W2042265810 @default.
• W2054319806 cites W2044796770 @default.
• W2054319806 cites W2057382033 @default.
• W2054319806 cites W2065695385 @default.
• W2054319806 cites W2086401698 @default.
• W2054319806 cites W2101027166 @default.
• W2054319806 cites W2109551775 @default.
• W2054319806 cites W2163186208 @default.
• W2054319806 cites W2169497835 @default.
• W2054319806 cites W4211126864 @default.
• W2054319806 cites W4244344354 @default.
• W2054319806 doi "https://doi.org/10.1158/0008-5472.can-05-0154" @default.
• W2054319806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16061668" @default.
• W2054319806 hasPublicationYear "2005" @default.
• W2054319806 type Work @default.
• W2054319806 sameAs 2054319806 @default.
• W2054319806 citedByCount "91" @default.
• W2054319806 countsByYear W20543198062012 @default.
• W2054319806 countsByYear W20543198062013 @default.
• W2054319806 countsByYear W20543198062014 @default.
• W2054319806 countsByYear W20543198062015 @default.
• W2054319806 countsByYear W20543198062016 @default.
• W2054319806 countsByYear W20543198062017 @default.
• W2054319806 countsByYear W20543198062018 @default.
• W2054319806 countsByYear W20543198062019 @default.
• W2054319806 countsByYear W20543198062021 @default.
• W2054319806 countsByYear W20543198062023 @default.
• W2054319806 crossrefType "journal-article" @default.
• W2054319806 hasAuthorship W2054319806A5003547110 @default.
• W2054319806 hasAuthorship W2054319806A5010422151 @default.
• W2054319806 hasAuthorship W2054319806A5032094946 @default.
• W2054319806 hasAuthorship W2054319806A5033917464 @default.
• W2054319806 hasAuthorship W2054319806A5058502526 @default.
• W2054319806 hasAuthorship W2054319806A5065678645 @default.
• W2054319806 hasAuthorship W2054319806A5076493366 @default.
• W2054319806 hasAuthorship W2054319806A5077387268 @default.
• W2054319806 hasAuthorship W2054319806A5078921760 @default.
• W2054319806 hasBestOaLocation W20543198061 @default.
• W2054319806 hasConcept C108215921 @default.
• W2054319806 hasConcept C121608353 @default.
• W2054319806 hasConcept C159047783 @default.
• W2054319806 hasConcept C2522874641 @default.
• W2054319806 hasConcept C2776694085 @default.
• W2054319806 hasConcept C2776755627 @default.
• W2054319806 hasConcept C2778227246 @default.
• W2054319806 hasConcept C2780259306 @default.
• W2054319806 hasConcept C2781196997 @default.
• W2054319806 hasConcept C502942594 @default.
• W2054319806 hasConcept C526805850 @default.
• W2054319806 hasConcept C54355233 @default.
• W2054319806 hasConcept C82210918 @default.
• W2054319806 hasConcept C86803240 @default.
• W2054319806 hasConcept C98274493 @default.
• W2054319806 hasConceptScore W2054319806C108215921 @default.
• W2054319806 hasConceptScore W2054319806C121608353 @default.
• W2054319806 hasConceptScore W2054319806C159047783 @default.
• W2054319806 hasConceptScore W2054319806C2522874641 @default.
• W2054319806 hasConceptScore W2054319806C2776694085 @default.
• W2054319806 hasConceptScore W2054319806C2776755627 @default.
• W2054319806 hasConceptScore W2054319806C2778227246 @default.
• W2054319806 hasConceptScore W2054319806C2780259306 @default.
• W2054319806 hasConceptScore W2054319806C2781196997 @default.
• W2054319806 hasConceptScore W2054319806C502942594 @default.
• W2054319806 hasConceptScore W2054319806C526805850 @default.
• W2054319806 hasConceptScore W2054319806C54355233 @default.
• W2054319806 hasConceptScore W2054319806C82210918 @default.
• W2054319806 hasConceptScore W2054319806C86803240 @default.
• W2054319806 hasConceptScore W2054319806C98274493 @default.
• W2054319806 hasIssue "15" @default.
• W2054319806 hasLocation W20543198061 @default.
• W2054319806 hasLocation W20543198062 @default.
• W2054319806 hasOpenAccess W2054319806 @default.
• W2054319806 hasPrimaryLocation W20543198061 @default.

• next