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• W2054321125 startingPage "140" @default.
• W2054321125 abstract "The distribution of somatostatin (SOM), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), tyrosine hydroxylase (a marker of noradrenergic neurons, NA) and nitric oxide synthase-immunoreactivity (NOS-IR) was examined in the inferior mesenteric ganglion of guinea pigs with double- and triple-labelling immunohistochemistry. About 75% of neurons identified were NA/SOM, almost 20% were NA/NPY and the remainder consisted of small groups of NA/-(1–5%), NA/NPY/SOM (2–5%) and VIP (1–2%) neurons. VIP neurons contained NPY-IR, usually contained SOM-IR and were surrounded by dense pericellular baskets of SP fibres. NOS-IR was found in a small proportion of neurons colocalized with VIP but both NOS- and VIP-IR were also found alone in some neurons. Some NOS reactive varicose fibres throughout the ganglia also contained VIP-IR but much of the NOS- and VIP-IR appeared to be localized in discrete varicosities. SOM-IR was also detectable in TH fibres within myenteric ganglia of the distal colon. We conclude that the subtypes of neurons in the inferior mesenteric ganglion share some properties with other sympathetic and abdominal ganglia but they exist in distinct proportions and may make dissimilar projections along the length of the gut." @default.
• W2054321125 created "2016-06-24" @default.
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• W2054321125 date "1996-07-01" @default.
• W2054321125 modified "2023-09-24" @default.
• W2054321125 title "Immunohistochemically-defined subtypes of neurons in the inferior mesenteric ganglion of the guinea-pig" @default.
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• W2054321125 doi "https://doi.org/10.1016/0165-1838(96)00017-3" @default.
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