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- W2054330700 abstract "Among five carboxamide derivatives (13–17), N-(2-dimethylaminoethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione-2-carboxamide (13) showed the greatest enhancement of all-trans retinoid acid (ATRA)-induced differentiation in HL-60 cells, inducing nearly complete differentiation at a concentration of 0.02 μM. On the other hand, 2-hydroxymethyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (2) and 2-(1-hydroxylethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (18) exhibited excellent and equally potent differentiation effects on HL-60 cells. To improve their water solubility, ester-type hydrophilic prodrugs (23–26) were also synthesized. Compounds 13 and 23–26 are identified in this paper as new anti-leukemic drug candidates." @default.
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- W2054330700 date "2007-05-01" @default.
- W2054330700 modified "2023-09-27" @default.
- W2054330700 title "Cell differentiation enhancement by hydrophilic derivatives of 4,8-Dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-diones in HL-60 leukemia cells" @default.
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- W2054330700 doi "https://doi.org/10.1016/j.bmcl.2007.02.044" @default.
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