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- W2054332344 abstract "Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3−11) from the marine sponge Phyllospongia dendyi collected from Palau. The structures were assigned on the basis of their spectral data. Compounds 3, 7, and 10 showed inhibitory activities to the assembly of microtubule proteins (IC50: 29.6, 33.5, and 20.9 μM, respectively) and to the meiotic maturation of starfish oocytes (IC50: 3.6, 4.2, and 4.2 μM, respectively), while 1, 2, 4−6, 8, 9, and 11 were not active at 100 μM. Two phenolic hydroxyls are required for their bioactivities." @default.
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- W2054332344 date "2004-01-21" @default.
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- W2054332344 title "Isolation and Characterization of Polybrominated Diphenyl Ethers as Inhibitors of Microtubule Assembly from the Marine Sponge <i>Phyllospongia </i><i>d</i><i>endyi</i> Collected at Palau" @default.
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- W2054332344 doi "https://doi.org/10.1021/np0304621" @default.
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