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- W2054338068 abstract "The hematopoietic transcription factor GATA-1 is essential for development of the erythroid and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of GATA-1 in the yeast two- hybrid system, we have identified a novel, multitype zinc finger protein, riend f ATA-1 (FOG), which binds GATA-1 but not a functionally inactive mutant lacking the amino (N) finger. FOG is coexpressed with GATA-1 during embryonic development and in erythroid and megakaryocytic cells. Furthermore, FOG and GATA-1 synergistically activate transcription from a hematopoietic-specific regulatory region and cooperate during both erythroid and megakaryocytic cell differentiation. These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors." @default.
- W2054338068 created "2016-06-24" @default.
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- W2054338068 date "1997-07-01" @default.
- W2054338068 modified "2023-10-11" @default.
- W2054338068 title "FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation" @default.
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- W2054338068 doi "https://doi.org/10.1016/s0092-8674(00)80318-9" @default.
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