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- W2054339986 abstract "The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 ± 4 percent in 10-month-old mice and by 58 ± 9 percent in 30-month-old mice compared with mice 3 months old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10- and 30-month-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence." @default.
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- W2054339986 date "1981-08-07" @default.
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- W2054339986 title "Brain Acetylcholine Synthesis Declines with Senescence" @default.
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- W2054339986 doi "https://doi.org/10.1126/science.7256270" @default.
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