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- W2054351652 abstract "The steroid, 17β-oestradiol (E2) has pervasive psychological and physical effects throughout the lifespan. The question arises as to whether there are divergent oestrogen receptor (ER)-mediated mechanisms for these effects in the central nervous system (CNS) and periphery. This review focuses on results of studies using a whole animal model (i.e. female rats and mice) to investigate the relative effects and mechanisms of oestrogens in the CNS and the periphery. By using this approach, it has been possible to differentiate the enhancing effects of E2 on behavioural processes mediated by the hippocampus, such as affective behaviour, and the trophic effects that increase tumourigenesis and uterine growth. Studies using pharmacological manipulations and knockout mice suggest that a likely mechanism underlying the beneficial effects of E2 for hippocampal function (but not proliferative effects in the body) involves actions at ERβ, changes in cell cycle/division (e.g. cyclin D1) and/or histone modifications. Thus, it may be possible to differentiate the beneficial effects of oestrogens through ERβ, particularly in the CNS, from the negative proliferative effects on peripheral, E2-sensitive tissues." @default.
- W2054351652 created "2016-06-24" @default.
- W2054351652 creator A5077485513 @default.
- W2054351652 date "2010-02-01" @default.
- W2054351652 modified "2023-10-07" @default.
- W2054351652 title "Oestrogen Receptor β is Involved in the Actions of Oestrogens in the Brain for Affective Behaviour, but not Trophic Effects in Peripheral Tissues" @default.
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- W2054351652 cites W1977571517 @default.
- W2054351652 cites W1977862283 @default.
- W2054351652 cites W1980724469 @default.
- W2054351652 cites W1982101277 @default.
- W2054351652 cites W1986022691 @default.
- W2054351652 cites W1996167112 @default.
- W2054351652 cites W1998866086 @default.
- W2054351652 cites W1999529766 @default.
- W2054351652 cites W2004042726 @default.
- W2054351652 cites W2005076717 @default.
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- W2054351652 cites W2006369650 @default.
- W2054351652 cites W2006561075 @default.
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- W2054351652 cites W2013330474 @default.
- W2054351652 cites W2015525713 @default.
- W2054351652 cites W2018513134 @default.
- W2054351652 cites W2024726601 @default.
- W2054351652 cites W2024960695 @default.
- W2054351652 cites W2026257763 @default.
- W2054351652 cites W2028155268 @default.
- W2054351652 cites W2031518606 @default.
- W2054351652 cites W2031577596 @default.
- W2054351652 cites W2034261103 @default.
- W2054351652 cites W2036862160 @default.
- W2054351652 cites W2040801339 @default.
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- W2054351652 cites W2062244421 @default.
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- W2054351652 cites W2070218253 @default.
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- W2054351652 cites W2070933716 @default.
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- W2054351652 cites W2073325756 @default.
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- W2054351652 cites W2162934389 @default.
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- W2054351652 cites W2189725743 @default.
- W2054351652 cites W2312557378 @default.
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- W2054351652 doi "https://doi.org/10.1111/j.1365-2826.2009.01945.x" @default.
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