Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054354013> ?p ?o ?g. }
- W2054354013 endingPage "1256" @default.
- W2054354013 startingPage "1245" @default.
- W2054354013 abstract "BACKGROUND Inositol hexakisphosphate (IP6) is a phytochemical exhibiting anticancer activity. Because few prostate cancer (PCa) cell lines have been used to study IP6, we assessed its efficacy in a panel of PCa cell lines. METHODS AND RESULTS Using WST-1 assays we observed that, although androgens did not modulate its efficacy, IP6 was more active in androgen receptor (AR) negative cells than in AR-positive cells. Stable expression of the AR in PC3 cells (PC3(AR)) decreased the response to IP6, which was reversed by an AR-targeting siRNA. Furthermore, AR expression in PC3 cells resulted in significantly reduced caspase-3 activation (P < 0.001) and DNA fragmentation (P < 0.05) in response to IP6. Similarly, although treatment with IP6 caused the upregulation of NF-κB-responsive (IκB-α, IRF-2) and p53/E2F-responsive genes (Puma, Noxa) in PC3 cells, this increase was reduced in PC3AR cells (P < 0.01). CONCLUSION We conclude that resistance to IP6 can be linked to a ligand-independent AR function. Prostate © 2006 Wiley-Liss, Inc." @default.
- W2054354013 created "2016-06-24" @default.
- W2054354013 creator A5038838890 @default.
- W2054354013 creator A5052794976 @default.
- W2054354013 creator A5053749991 @default.
- W2054354013 creator A5057962754 @default.
- W2054354013 creator A5067259381 @default.
- W2054354013 creator A5070217428 @default.
- W2054354013 creator A5079572081 @default.
- W2054354013 date "2006-01-01" @default.
- W2054354013 modified "2023-10-10" @default.
- W2054354013 title "An androgen-independent androgen receptor function protects from inositol hexakisphosphate toxicity in the PC3/PC3(AR) prostate cancer cell lines" @default.
- W2054354013 cites W1493920337 @default.
- W2054354013 cites W1605507149 @default.
- W2054354013 cites W1849819493 @default.
- W2054354013 cites W1964464646 @default.
- W2054354013 cites W1973010816 @default.
- W2054354013 cites W1991074325 @default.
- W2054354013 cites W2002801265 @default.
- W2054354013 cites W2005435076 @default.
- W2054354013 cites W2007456673 @default.
- W2054354013 cites W2010298858 @default.
- W2054354013 cites W2011485328 @default.
- W2054354013 cites W2012147443 @default.
- W2054354013 cites W2019822560 @default.
- W2054354013 cites W2023018072 @default.
- W2054354013 cites W2027686496 @default.
- W2054354013 cites W2030982520 @default.
- W2054354013 cites W2050567539 @default.
- W2054354013 cites W2051831012 @default.
- W2054354013 cites W2062117095 @default.
- W2054354013 cites W2064293531 @default.
- W2054354013 cites W2065343028 @default.
- W2054354013 cites W2070851174 @default.
- W2054354013 cites W2071914496 @default.
- W2054354013 cites W2075172606 @default.
- W2054354013 cites W2078804130 @default.
- W2054354013 cites W2081145901 @default.
- W2054354013 cites W2084647824 @default.
- W2054354013 cites W2087127386 @default.
- W2054354013 cites W2094181802 @default.
- W2054354013 cites W2104762821 @default.
- W2054354013 cites W2108244474 @default.
- W2054354013 cites W2115648461 @default.
- W2054354013 cites W2125639857 @default.
- W2054354013 cites W2126071672 @default.
- W2054354013 cites W2133506204 @default.
- W2054354013 cites W2136294116 @default.
- W2054354013 cites W2138123431 @default.
- W2054354013 cites W2139966647 @default.
- W2054354013 cites W2144023014 @default.
- W2054354013 cites W2146021996 @default.
- W2054354013 cites W2154644423 @default.
- W2054354013 cites W2157723631 @default.
- W2054354013 cites W2160688175 @default.
- W2054354013 cites W2162847017 @default.
- W2054354013 cites W2164916751 @default.
- W2054354013 cites W2169915942 @default.
- W2054354013 cites W2984785086 @default.
- W2054354013 doi "https://doi.org/10.1002/pros.20455" @default.
- W2054354013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16705740" @default.
- W2054354013 hasPublicationYear "2006" @default.
- W2054354013 type Work @default.
- W2054354013 sameAs 2054354013 @default.
- W2054354013 citedByCount "15" @default.
- W2054354013 countsByYear W20543540132012 @default.
- W2054354013 countsByYear W20543540132014 @default.
- W2054354013 countsByYear W20543540132020 @default.
- W2054354013 countsByYear W20543540132021 @default.
- W2054354013 countsByYear W20543540132022 @default.
- W2054354013 crossrefType "journal-article" @default.
- W2054354013 hasAuthorship W2054354013A5038838890 @default.
- W2054354013 hasAuthorship W2054354013A5052794976 @default.
- W2054354013 hasAuthorship W2054354013A5053749991 @default.
- W2054354013 hasAuthorship W2054354013A5057962754 @default.
- W2054354013 hasAuthorship W2054354013A5067259381 @default.
- W2054354013 hasAuthorship W2054354013A5070217428 @default.
- W2054354013 hasAuthorship W2054354013A5079572081 @default.
- W2054354013 hasConcept C104317684 @default.
- W2054354013 hasConcept C121608353 @default.
- W2054354013 hasConcept C126322002 @default.
- W2054354013 hasConcept C127561419 @default.
- W2054354013 hasConcept C134018914 @default.
- W2054354013 hasConcept C170493617 @default.
- W2054354013 hasConcept C185592680 @default.
- W2054354013 hasConcept C190283241 @default.
- W2054354013 hasConcept C2777427919 @default.
- W2054354013 hasConcept C2777911890 @default.
- W2054354013 hasConcept C2780192828 @default.
- W2054354013 hasConcept C502942594 @default.
- W2054354013 hasConcept C54355233 @default.
- W2054354013 hasConcept C55493867 @default.
- W2054354013 hasConcept C61367390 @default.
- W2054354013 hasConcept C71315377 @default.
- W2054354013 hasConcept C71924100 @default.
- W2054354013 hasConcept C81885089 @default.
- W2054354013 hasConcept C86803240 @default.
- W2054354013 hasConceptScore W2054354013C104317684 @default.