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- W2054356983 abstract "MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino acid MutT module. The cloned mouse MTH2 (mMTH2) cDNA was expressed in Escherichia coli mutT− cells and the protein was purified. mMTH2 protein hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, with Km of 32 μM. Expression of cDNA for mMTH2 reduced significantly the elevated level of spontaneous mutation frequency of E. coli mutT− cells. Thus, MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals. MTH2 could act as an MTH1 redundancy factor." @default.
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- W2054356983 date "2003-06-01" @default.
- W2054356983 modified "2023-10-01" @default.
- W2054356983 title "Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides" @default.
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- W2054356983 doi "https://doi.org/10.1016/s0006-291x(03)00864-7" @default.
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