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• W2054358119 endingPage "412" @default.
• W2054358119 startingPage "387" @default.
• W2054358119 abstract "The Duffy blood group has five antigenic specificities, Fya, Fyb, Fy3, Fy4, and Fy5, that are part of, or related to, the system. The first four antigens are under the genetic control of a locus near the centromere of chromosome 1. Fy5 antigen is absent on red cells that lack both Fya and Fyb, and it is also absent from cells that have the Rhnull phenotype. This suggests that Fy5 may require contributions by Duffy and Rhesus gene products for its synthesis or proper orientation on the cell membrane.The great majority of Caucasians have an Fya or Fyb gene (or both) inherited by strict Mendelian principles. No evidence has been found to suggest that independently segregating modifying genes affect the expression of Duffy. The frequency of different Duffy genes varies greatly in different sections of the world population. Aborigines of Australia and New Guinea have a high frequency of Fya, Fyb is the most common gene in European Caucasians, and Negroes have a high frequency of an allele named Fy. Until recently, Fy was thought to represent an amorph, but the antibody named anti-Fy4 now seems to define an antigenic product. The exact genetic interrelationship of the different Duffy types is not yet clear, but it is possible that Fya and Fyb are alleles and that Fy3 and Fy4 also have an allelic relationship at a Duffy sublocus.Anti-Fya is most common of the Duffy antibodies and occurs most frequently in the serum of Caucasian patients who have been immunized by blood transfusion. The Fya antigen appears to be about 40 times less immunogenic than K of the Kell system. Fyb is considerably less immunogenic than Fya, and about 1 serum with anti-Fyb specificity is found for every 20 that are anti-Fya. Only a few examples of anti-Fy3, anti-Fy4, and anti-Fy5 have been found.Incompatibility involving anti-Fya may cause severe reactions to blood transfusion. The Duffy antigens, with possible exception of Fy3, appear to be strongly active on fetal red cells, and on rare occasions anti-Fya may be responsible for hemolytic disease in the newborn. Anti-Fyb does not appear to have as great a capability of producing severe in vivo hemolysis as does anti-Fya.The Fya and Fyb antigens of red cells are inactivated by various proteolytic enzymes, but they are not inactivated by neuraminidase. Sialic acid does not appear to be an essential component of the antigenic determinant. The Fy3, Fy4, and Fy5 antigens are not inactivated if red cells are treated with proteolytic enzymes. Duffy antigens appear to be thermolabile proteins and are not present in a soluble form in body secretions or in plasma. Phylogenetic studies in primates indicate that Fya may be a mutant found in man, but Fyb is present in other primate species. Fy3 appears to be the oldest gene is evolutionary terms." @default.
• W2054358119 created "2016-06-24" @default.
• W2054358119 creator A5062072045 @default.
• W2054358119 date "1975-01-01" @default.
• W2054358119 modified "2023-09-23" @default.
• W2054358119 title "Present Status of the Duffy Blood Group System: Articles Reviewed" @default.
• W2054358119 cites W1559975799 @default.
• W2054358119 cites W169498033 @default.
• W2054358119 cites W1963936169 @default.
• W2054358119 cites W1964524175 @default.
• W2054358119 cites W1964529864 @default.
• W2054358119 cites W1969266136 @default.
• W2054358119 cites W1969690444 @default.
• W2054358119 cites W1970045516 @default.
• W2054358119 cites W1970093704 @default.
• W2054358119 cites W1972644802 @default.
• W2054358119 cites W1972759544 @default.
• W2054358119 cites W1975586323 @default.
• W2054358119 cites W1984534798 @default.
• W2054358119 cites W1985697191 @default.
• W2054358119 cites W1989503251 @default.
• W2054358119 cites W1989873046 @default.
• W2054358119 cites W1989922258 @default.
• W2054358119 cites W1991301946 @default.
• W2054358119 cites W1996895249 @default.
• W2054358119 cites W1999346311 @default.
• W2054358119 cites W2001660714 @default.
• W2054358119 cites W2005511716 @default.
• W2054358119 cites W2005527082 @default.
• W2054358119 cites W2006078866 @default.
• W2054358119 cites W2006810762 @default.
• W2054358119 cites W2008977539 @default.
• W2054358119 cites W2011415063 @default.
• W2054358119 cites W2016946379 @default.
• W2054358119 cites W2022766876 @default.
• W2054358119 cites W2023822795 @default.
• W2054358119 cites W2029908683 @default.
• W2054358119 cites W2031720211 @default.
• W2054358119 cites W2031817513 @default.
• W2054358119 cites W2033178646 @default.
• W2054358119 cites W2033203401 @default.
• W2054358119 cites W2034620261 @default.
• W2054358119 cites W2034884916 @default.
• W2054358119 cites W2037626730 @default.
• W2054358119 cites W2038204679 @default.
• W2054358119 cites W2045146024 @default.
• W2054358119 cites W2047238431 @default.
• W2054358119 cites W2051203850 @default.
• W2054358119 cites W2054336455 @default.
• W2054358119 cites W2055574221 @default.
• W2054358119 cites W2062698592 @default.
• W2054358119 cites W2062809369 @default.
• W2054358119 cites W2062881923 @default.
• W2054358119 cites W2063646841 @default.
• W2054358119 cites W2063665312 @default.
• W2054358119 cites W2064717299 @default.
• W2054358119 cites W2067392755 @default.
• W2054358119 cites W2069714206 @default.
• W2054358119 cites W2070188409 @default.
• W2054358119 cites W2073288651 @default.
• W2054358119 cites W2074271196 @default.
• W2054358119 cites W2075248694 @default.
• W2054358119 cites W2075812056 @default.
• W2054358119 cites W2080529770 @default.
• W2054358119 cites W2082181892 @default.
• W2054358119 cites W2083803847 @default.
• W2054358119 cites W2086155820 @default.
• W2054358119 cites W2086526800 @default.
• W2054358119 cites W2088274041 @default.
• W2054358119 cites W2088425079 @default.
• W2054358119 cites W2091530740 @default.
• W2054358119 cites W2092745583 @default.
• W2054358119 cites W2093347002 @default.
• W2054358119 cites W2098670466 @default.
• W2054358119 cites W2100867014 @default.
• W2054358119 cites W2120670440 @default.
• W2054358119 cites W2123828628 @default.
• W2054358119 cites W2126006327 @default.
• W2054358119 cites W2129701686 @default.
• W2054358119 cites W2144670782 @default.
• W2054358119 cites W2157774018 @default.
• W2054358119 cites W2160788935 @default.
• W2054358119 cites W2172265018 @default.
• W2054358119 cites W2245711703 @default.
• W2054358119 cites W2318081291 @default.
• W2054358119 cites W2525741419 @default.
• W2054358119 cites W349246563 @default.
• W2054358119 cites W4321509060 @default.
• W2054358119 doi "https://doi.org/10.3109/10408367509107049" @default.
• W2054358119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/49254" @default.
• W2054358119 hasPublicationYear "1975" @default.
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