Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054369519> ?p ?o ?g. }
- W2054369519 endingPage "414" @default.
- W2054369519 startingPage "410" @default.
- W2054369519 abstract "Abstract Background: Current evidence suggests that immunological mechanisms are involved in oral lichen planus (OLP) pathogenesis. The events implicate activated epithelia that comprise antigen‐presenting Langerhans cells, immunocompetent keratinocytes and subepithelial inflammatory infiltrate. Also, the presence of a high density of leucocyte cells may occur for the expression of a variety of adhesion molecules. The aim of this study was to analyse the immunoexpression of some adhesion molecules as well as lymphocytic markers in order to determine the disease pathogenesis in a Venezuelan population. Methods: The 18 OLP and 10 normal oral mucosa biopsies were immunostained for CD4, CD8, CD1a, LFA‐1, VCAM‐1 and ICAM‐1. Results: The results showed an increased number of CD4+, CD8+, CD1a+ cells in OLP. Serial sections showed CD4+ and CD8+ cells also expressed LFA‐1. The expression of ICAM‐1 and VCAM‐1 were significantly higher in OLP. Conclusions: The immunological reaction begins with Langerhans cells activation, which presents an antigen to CD4+ lymphocytes. Those cells through ICAM‐1 and LFA‐1 promote epithelial destruction. Afterwards, cytokine production, ICAM‐1 and VCAM‐1 expression can activate CD8+ lymphocytes leading to the chronic form of the disease." @default.
- W2054369519 created "2016-06-24" @default.
- W2054369519 creator A5013748292 @default.
- W2054369519 creator A5026229031 @default.
- W2054369519 creator A5044400552 @default.
- W2054369519 creator A5061248147 @default.
- W2054369519 date "2002-08-01" @default.
- W2054369519 modified "2023-10-18" @default.
- W2054369519 title "Oral lichen planus: immunohistology of mucosal lesions" @default.
- W2054369519 cites W1743189389 @default.
- W2054369519 cites W1963936317 @default.
- W2054369519 cites W1966286149 @default.
- W2054369519 cites W1969783034 @default.
- W2054369519 cites W1972749612 @default.
- W2054369519 cites W1972932426 @default.
- W2054369519 cites W1979977831 @default.
- W2054369519 cites W1984512440 @default.
- W2054369519 cites W1987477919 @default.
- W2054369519 cites W1990877415 @default.
- W2054369519 cites W1991371980 @default.
- W2054369519 cites W1993361752 @default.
- W2054369519 cites W2003307963 @default.
- W2054369519 cites W2005567435 @default.
- W2054369519 cites W2006146779 @default.
- W2054369519 cites W2010358369 @default.
- W2054369519 cites W2015517758 @default.
- W2054369519 cites W2018679247 @default.
- W2054369519 cites W2019354232 @default.
- W2054369519 cites W2021034171 @default.
- W2054369519 cites W2022766957 @default.
- W2054369519 cites W2023646637 @default.
- W2054369519 cites W2029403964 @default.
- W2054369519 cites W2030716595 @default.
- W2054369519 cites W2035463069 @default.
- W2054369519 cites W2057784785 @default.
- W2054369519 cites W2060043588 @default.
- W2054369519 cites W2068218908 @default.
- W2054369519 cites W2070461648 @default.
- W2054369519 cites W2073465783 @default.
- W2054369519 cites W2074906410 @default.
- W2054369519 cites W2079177956 @default.
- W2054369519 cites W2079277469 @default.
- W2054369519 cites W2079941510 @default.
- W2054369519 cites W2080950207 @default.
- W2054369519 cites W2089112337 @default.
- W2054369519 cites W2089997124 @default.
- W2054369519 cites W2096428903 @default.
- W2054369519 cites W2165518867 @default.
- W2054369519 cites W2167936032 @default.
- W2054369519 cites W242464715 @default.
- W2054369519 doi "https://doi.org/10.1034/j.1600-0714.2002.00097.x" @default.
- W2054369519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12165059" @default.
- W2054369519 hasPublicationYear "2002" @default.
- W2054369519 type Work @default.
- W2054369519 sameAs 2054369519 @default.
- W2054369519 citedByCount "80" @default.
- W2054369519 countsByYear W20543695192012 @default.
- W2054369519 countsByYear W20543695192013 @default.
- W2054369519 countsByYear W20543695192014 @default.
- W2054369519 countsByYear W20543695192015 @default.
- W2054369519 countsByYear W20543695192016 @default.
- W2054369519 countsByYear W20543695192017 @default.
- W2054369519 countsByYear W20543695192018 @default.
- W2054369519 countsByYear W20543695192019 @default.
- W2054369519 countsByYear W20543695192020 @default.
- W2054369519 countsByYear W20543695192021 @default.
- W2054369519 countsByYear W20543695192022 @default.
- W2054369519 countsByYear W20543695192023 @default.
- W2054369519 crossrefType "journal-article" @default.
- W2054369519 hasAuthorship W2054369519A5013748292 @default.
- W2054369519 hasAuthorship W2054369519A5026229031 @default.
- W2054369519 hasAuthorship W2054369519A5044400552 @default.
- W2054369519 hasAuthorship W2054369519A5061248147 @default.
- W2054369519 hasConcept C142724271 @default.
- W2054369519 hasConcept C147483822 @default.
- W2054369519 hasConcept C16224149 @default.
- W2054369519 hasConcept C167672396 @default.
- W2054369519 hasConcept C203014093 @default.
- W2054369519 hasConcept C2776201145 @default.
- W2054369519 hasConcept C2778690821 @default.
- W2054369519 hasConcept C2780942790 @default.
- W2054369519 hasConcept C2908647359 @default.
- W2054369519 hasConcept C71924100 @default.
- W2054369519 hasConcept C86803240 @default.
- W2054369519 hasConcept C99454951 @default.
- W2054369519 hasConceptScore W2054369519C142724271 @default.
- W2054369519 hasConceptScore W2054369519C147483822 @default.
- W2054369519 hasConceptScore W2054369519C16224149 @default.
- W2054369519 hasConceptScore W2054369519C167672396 @default.
- W2054369519 hasConceptScore W2054369519C203014093 @default.
- W2054369519 hasConceptScore W2054369519C2776201145 @default.
- W2054369519 hasConceptScore W2054369519C2778690821 @default.
- W2054369519 hasConceptScore W2054369519C2780942790 @default.
- W2054369519 hasConceptScore W2054369519C2908647359 @default.
- W2054369519 hasConceptScore W2054369519C71924100 @default.
- W2054369519 hasConceptScore W2054369519C86803240 @default.
- W2054369519 hasConceptScore W2054369519C99454951 @default.
- W2054369519 hasIssue "7" @default.