FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054374025> ?p ?o ?g. }

• W2054374025 endingPage "873" @default.
• W2054374025 startingPage "863" @default.
• W2054374025 abstract "A number of in vitro and in vivo studies using selective agonists have indicated a neuroprotective role for group-II metabotropic glutamate (mGlu2/3) receptors in various models of neuronal injury. Although an interplay among neurotrophic factors and mGlu2/3 receptors signalling system has been suggested as possible mechanism involved on neuroprotection, at present poor information are available concerning the in vivo regulation by mGlu2/3 receptors activation of specific neurotrophic factors. By using in situ hybridization and western blotting methods the aim of present study was to analyse the potential regulatory role of selective mGluR2/3 agonist LY379268 treatment on brain derived neurotrophic factor (BDNF) expression in the mouse brain. The treatment with LY379268 evidenced a significant upregulation of BDNF mRNA levels in the cerebral cortex and in the hippocampal formation with a peak at 3 h from treatment and its disappearance already at 6 h from treatment. An analysis of dose-effect curve revealed that LY379268 may significantly enhance BDNF mRNA expression already at dose of 0.250 mg/kg b.w. The upregulation of BDNF mRNA expression was followed by a significant increase of BDNF protein levels at 24 h from LY379268 treatment. These effects of LY379268 treatment on BDNF expression were restricted to neuronal cells and were blocked by the new selective mGlu2/3 receptor antagonist LY341495, suggesting a receptor specificity. Taken together these findings suggest that several previous observed neuroprotective and trophic actions of mGluR2/3 agonists treatment may be mediated, at least in the cerebral cortex and hippocampal formation, by upregulation of BDNF expression." @default.
• W2054374025 created "2016-06-24" @default.
• W2054374025 creator A5005715456 @default.
• W2054374025 creator A5009375394 @default.
• W2054374025 creator A5022524921 @default.
• W2054374025 creator A5035378405 @default.
• W2054374025 creator A5058892129 @default.
• W2054374025 date "2010-02-01" @default.
• W2054374025 modified "2023-10-17" @default.
• W2054374025 title "Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain" @default.
• W2054374025 cites W117431324 @default.
• W2054374025 cites W1496088120 @default.
• W2054374025 cites W1501657654 @default.
• W2054374025 cites W1555679702 @default.
• W2054374025 cites W1563615702 @default.
• W2054374025 cites W1600525795 @default.
• W2054374025 cites W1775749144 @default.
• W2054374025 cites W1935475606 @default.
• W2054374025 cites W1965312515 @default.
• W2054374025 cites W1967075670 @default.
• W2054374025 cites W1978668014 @default.
• W2054374025 cites W1981993146 @default.
• W2054374025 cites W1988181966 @default.
• W2054374025 cites W1991542726 @default.
• W2054374025 cites W2002574600 @default.
• W2054374025 cites W2016413308 @default.
• W2054374025 cites W2017010915 @default.
• W2054374025 cites W2017505808 @default.
• W2054374025 cites W2018436424 @default.
• W2054374025 cites W2023434269 @default.
• W2054374025 cites W2026831468 @default.
• W2054374025 cites W2029533997 @default.
• W2054374025 cites W2029542833 @default.
• W2054374025 cites W2036256226 @default.
• W2054374025 cites W2037775711 @default.
• W2054374025 cites W2045628566 @default.
• W2054374025 cites W2047217496 @default.
• W2054374025 cites W2049659439 @default.
• W2054374025 cites W2050903686 @default.
• W2054374025 cites W2056667335 @default.
• W2054374025 cites W2057632749 @default.
• W2054374025 cites W2063089911 @default.
• W2054374025 cites W2063849763 @default.
• W2054374025 cites W2067226568 @default.
• W2054374025 cites W2067795636 @default.
• W2054374025 cites W2067874558 @default.
• W2054374025 cites W2073310162 @default.
• W2054374025 cites W2075250244 @default.
• W2054374025 cites W2078316783 @default.
• W2054374025 cites W2079472132 @default.
• W2054374025 cites W2079676087 @default.
• W2054374025 cites W2082049028 @default.
• W2054374025 cites W2085505779 @default.
• W2054374025 cites W2085673544 @default.
• W2054374025 cites W2088752130 @default.
• W2054374025 cites W2088947382 @default.
• W2054374025 cites W2094544368 @default.
• W2054374025 cites W2105012597 @default.
• W2054374025 cites W2119151345 @default.
• W2054374025 cites W2120272723 @default.
• W2054374025 cites W2122835512 @default.
• W2054374025 cites W2148950534 @default.
• W2054374025 cites W2154437375 @default.
• W2054374025 cites W2163639252 @default.
• W2054374025 doi "https://doi.org/10.1016/j.neuroscience.2009.11.012" @default.
• W2054374025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19909793" @default.
• W2054374025 hasPublicationYear "2010" @default.
• W2054374025 type Work @default.
• W2054374025 sameAs 2054374025 @default.
• W2054374025 citedByCount "39" @default.
• W2054374025 countsByYear W20543740252012 @default.
• W2054374025 countsByYear W20543740252014 @default.
• W2054374025 countsByYear W20543740252015 @default.
• W2054374025 countsByYear W20543740252016 @default.
• W2054374025 countsByYear W20543740252017 @default.
• W2054374025 countsByYear W20543740252018 @default.
• W2054374025 countsByYear W20543740252019 @default.
• W2054374025 countsByYear W20543740252020 @default.
• W2054374025 countsByYear W20543740252021 @default.
• W2054374025 countsByYear W20543740252022 @default.
• W2054374025 crossrefType "journal-article" @default.
• W2054374025 hasAuthorship W2054374025A5005715456 @default.
• W2054374025 hasAuthorship W2054374025A5009375394 @default.
• W2054374025 hasAuthorship W2054374025A5022524921 @default.
• W2054374025 hasAuthorship W2054374025A5035378405 @default.
• W2054374025 hasAuthorship W2054374025A5058892129 @default.
• W2054374025 hasConcept C119128870 @default.
• W2054374025 hasConcept C126322002 @default.
• W2054374025 hasConcept C134018914 @default.
• W2054374025 hasConcept C148762608 @default.
• W2054374025 hasConcept C15744967 @default.
• W2054374025 hasConcept C160539049 @default.
• W2054374025 hasConcept C169760540 @default.
• W2054374025 hasConcept C170493617 @default.
• W2054374025 hasConcept C185592680 @default.
• W2054374025 hasConcept C25498285 @default.
• W2054374025 hasConcept C26702167 @default.
• W2054374025 hasConcept C2778790584 @default.

• next