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- W2054389211 abstract "<h2>Abstract</h2><h3>Introduction</h3> Intestinal inflammation alters colonic afferent nerve sensitivity which may contribute to patients' perception of abdominal discomfort. We aimed to explore whether mast cells and the cyclooxygenase pathway are involved in altered afferent nerve sensitivity during colitis. <h3>Methods</h3> C57Bl6 mice received 3% dextran-sulfate sodium (DSS) in drinking water for 7days to induce colitis. Control animals received regular water. On day 8 inflammation was assessed in the proximal colon by morphology and histology. Extracellular afferent nerve discharge was recorded from the mesenteric nerve of a 2cm colonic segment. Subgroups were treated in vitro with the mast cell stabilizer doxantrazole (10<sup>−4</sup>M) or the cyclooxygenase inhibitor naproxen (10<sup>−5</sup>M). <h3>Results</h3> DSS colitis resulted in morphological and histological signs of inflammation. At baseline, peak firing was 11±2imps<sup>−1</sup> in colitis segments and 5±1imps<sup>−1</sup> in uninflamed control segments (p<0.05; mean±SEM; each n=6). In colitis segments, afferent nerve discharge to bradykinin (0.5μM) was increased to 47±7 compared to 23±6imps<sup>−1</sup> in recordings from non-inflamed control tissue (p<0.05). Mechanosensitivity during luminal ramp distension (0–80cmH<sub>2</sub>O) was increased reaching 24±5imps<sup>−1</sup> at 80cmH<sub>2</sub>O during colitis compared to 14±2 in non-inflamed controls (p<0.05). Doxantrazole or naproxen reduced afferent discharge to bradykinin and luminal ramp distension in colitis segments to control levels. <h3>Conclusion</h3> Intestinal inflammation sensitizes mesenteric afferent nerve fibers to bradykinin and mechanical stimuli. The underlying mechanism responsible for this sensitization seems to involve mast cells and prostaglandins." @default.
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- W2054389211 date "2013-03-01" @default.
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- W2054389211 title "Mast cells and the cyclooxygenase pathway mediate colonic afferent nerve sensitization in a murine colitis model" @default.
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- W2054389211 doi "https://doi.org/10.1016/j.autneu.2013.01.001" @default.
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