FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054392352> ?p ?o ?g. }

• W2054392352 endingPage "77" @default.
• W2054392352 startingPage "67" @default.
• W2054392352 abstract "Microsatellite DNA sequences display allele length alterations or microsatellite instability (MSI) in tumor tissues, and MSI is used diagnostically for tumor detection and classification. We discuss the known types of tumor-specific MSI patterns and the relevant mechanisms underlying each pattern. Mutation rates of individual microsatellites vary greatly, and the intrinsic DNA features of motif size, sequence, and length contribute to this variation. MSI is used for detecting mismatch repair (MMR)-deficient tumors, which display an MSI-high phenotype due to genome-wide microsatellite destabilization. Because several pathways maintain microsatellite stability, tumors that have undergone other events associated with moderate genome instability may display diagnostic MSI only at specific di- or tetranucleotide markers. We summarize evidence for such alternative MSI forms (A-MSI) in sporadic cancers, also referred to as MSI-low and EMAST. While the existence of A-MSI is not disputed, there is disagreement about the origin and pathologic significance of this phenomenon. Although ambiguities due to PCR methods may be a source, evidence exists for other mechanisms to explain tumor-specific A-MSI. Some portion of A-MSI tumors may result from random mutational events arising during neoplastic cell evolution. However, this mechanism fails to explain the specificity of A-MSI for di- and tetranucleotide instability. We present evidence supporting the alternative argument that some A-MSI tumors arise by a distinct genetic pathway, and give examples of DNA metabolic pathways that, when altered, may be responsible for instability at specific microsatellite motifs. Finally, we suggest that A-MSI in tumors could be molecular signatures of environmental influences and DNA damage. Importantly, A-MSI occurs in several pre-neoplastic inflammatory states, including inflammatory bowel diseases, consistent with a role of oxidative stress in A-MSI. Understanding the biochemical basis of A-MSI tumor phenotypes will advance the development of new diagnostic tools and positively impact the clinical management of individual cancers." @default.
• W2054392352 created "2016-06-24" @default.
• W2054392352 creator A5060097473 @default.
• W2054392352 creator A5065198328 @default.
• W2054392352 creator A5081932988 @default.
• W2054392352 date "2013-03-01" @default.
• W2054392352 modified "2023-10-12" @default.
• W2054392352 title "Tumor-specific microsatellite instability: Do distinct mechanisms underlie the MSI-L and EMAST phenotypes?" @default.
• W2054392352 cites W1522381329 @default.
• W2054392352 cites W1786881211 @default.
• W2054392352 cites W1963581476 @default.
• W2054392352 cites W1965219770 @default.
• W2054392352 cites W1965337318 @default.
• W2054392352 cites W1968110523 @default.
• W2054392352 cites W1969231537 @default.
• W2054392352 cites W1970064594 @default.
• W2054392352 cites W1972325598 @default.
• W2054392352 cites W1973244269 @default.
• W2054392352 cites W1973717764 @default.
• W2054392352 cites W1974631966 @default.
• W2054392352 cites W1974643906 @default.
• W2054392352 cites W1975595428 @default.
• W2054392352 cites W1976831386 @default.
• W2054392352 cites W1982056967 @default.
• W2054392352 cites W1986937402 @default.
• W2054392352 cites W1988902754 @default.
• W2054392352 cites W1990133999 @default.
• W2054392352 cites W1993329090 @default.
• W2054392352 cites W1995819860 @default.
• W2054392352 cites W1999131998 @default.
• W2054392352 cites W2006636612 @default.
• W2054392352 cites W2006764478 @default.
• W2054392352 cites W2009437756 @default.
• W2054392352 cites W2011367808 @default.
• W2054392352 cites W2016493248 @default.
• W2054392352 cites W2019935156 @default.
• W2054392352 cites W2022346160 @default.
• W2054392352 cites W2022388562 @default.
• W2054392352 cites W2023890131 @default.
• W2054392352 cites W2025551794 @default.
• W2054392352 cites W2026669150 @default.
• W2054392352 cites W2026819054 @default.
• W2054392352 cites W2030593279 @default.
• W2054392352 cites W2035426334 @default.
• W2054392352 cites W2036403522 @default.
• W2054392352 cites W2037936898 @default.
• W2054392352 cites W2040540105 @default.
• W2054392352 cites W2044643325 @default.
• W2054392352 cites W2044671527 @default.
• W2054392352 cites W2045044035 @default.
• W2054392352 cites W2047057598 @default.
• W2054392352 cites W2048179657 @default.
• W2054392352 cites W2053077867 @default.
• W2054392352 cites W2061343866 @default.
• W2054392352 cites W2064830314 @default.
• W2054392352 cites W2065329423 @default.
• W2054392352 cites W2066075766 @default.
• W2054392352 cites W2068906373 @default.
• W2054392352 cites W2070411073 @default.
• W2054392352 cites W2071858293 @default.
• W2054392352 cites W2071992651 @default.
• W2054392352 cites W2072779476 @default.
• W2054392352 cites W2074730941 @default.
• W2054392352 cites W2075637141 @default.
• W2054392352 cites W2075960489 @default.
• W2054392352 cites W2076538215 @default.
• W2054392352 cites W2078485114 @default.
• W2054392352 cites W2078730895 @default.
• W2054392352 cites W2084119626 @default.
• W2054392352 cites W2089237198 @default.
• W2054392352 cites W2094390470 @default.
• W2054392352 cites W2094651761 @default.
• W2054392352 cites W2096551220 @default.
• W2054392352 cites W2101455369 @default.
• W2054392352 cites W2101851224 @default.
• W2054392352 cites W2103340598 @default.
• W2054392352 cites W2110104100 @default.
• W2054392352 cites W2110808874 @default.
• W2054392352 cites W2112421940 @default.
• W2054392352 cites W2114889536 @default.
• W2054392352 cites W2121685690 @default.
• W2054392352 cites W2122083165 @default.
• W2054392352 cites W2124295966 @default.
• W2054392352 cites W2124581351 @default.
• W2054392352 cites W2125215178 @default.
• W2054392352 cites W2125957956 @default.
• W2054392352 cites W2127951115 @default.
• W2054392352 cites W2128471216 @default.
• W2054392352 cites W2128793721 @default.
• W2054392352 cites W2130544215 @default.
• W2054392352 cites W2133644328 @default.
• W2054392352 cites W2134420941 @default.
• W2054392352 cites W2136684540 @default.
• W2054392352 cites W2148300747 @default.
• W2054392352 cites W2150280162 @default.
• W2054392352 cites W2151789179 @default.
• W2054392352 cites W2153459501 @default.
• W2054392352 cites W2155941473 @default.

• next