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- W2054394474 abstract "Rats with portacaval shunt, although showing no changes in their spontaneous pain threshold, did display an increased sensitivity of analgesic responses to morphine injection. In addition, these portacaval-shunted animals had a lower level of spontaneous motor activity and a reduced sensitivity of locomotor stimulant responses to amphetamine administration. However, these portacaval-shunted animals displayed same thermoregulatory responses to various ambient temperatures as those of normal unoperated or sham-operated animals. Biochemical examination revealed that these portacaval-shunted animals had a higher indoleamine synthesis in both the hypothalamus and the brain stem, but had a lower catecholamine synthesis in both the hypothalamus and the corpus striatum. The data suggest that alterations in antinociceptive and locomotor stimulant responses of the portacaval-shunted animals correlate with patterns of monoamine synthesis in different brain regions (patterns that differed from those observed in normal unoperated animals or in sham-operated animals)." @default.
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- W2054394474 date "1988-01-01" @default.
- W2054394474 modified "2023-09-26" @default.
- W2054394474 title "Alteration in Antinociception, Locomotion and Brain Monoamine Synthesis in Rats with Portacaval Shunts" @default.
- W2054394474 doi "https://doi.org/10.1159/000138409" @default.
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