Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054395586> ?p ?o ?g. }
- W2054395586 abstract "Escherichia coli RidA is a member of a structurally conserved, yet functionally highly diverse protein family involved in translation inhibition (human), Hsp90-like chaperone activity (fruit fly) and enamine/imine deamination (Salmonella enterica). Here, we show that E. coli RidA modified with HOCl acts as a highly effective chaperone. Although activation of RidA is reversed by treatment with DTT, ascorbic acid, the thioredoxin system and glutathione, it is independent of cysteine modification. Instead, treatment with HOCl or chloramines decreases the amino group content of RidA by reversibly N-chlorinating positively charged residues. N-chlorination increases hydrophobicity of RidA and promotes binding to a wide spectrum of unfolded cytosolic proteins. Deletion of ridA results in an HOCl-sensitive phenotype. HOCl-mediated N-chlorination thus is a cysteine-independent post-translational modification that reversibly turns RidA into an effective chaperone holdase, which plays a crucial role in the protection of cytosolic proteins during oxidative stress." @default.
- W2054395586 created "2016-06-24" @default.
- W2054395586 creator A5003029797 @default.
- W2054395586 creator A5016264987 @default.
- W2054395586 creator A5017760059 @default.
- W2054395586 creator A5031194392 @default.
- W2054395586 creator A5034841136 @default.
- W2054395586 creator A5042600518 @default.
- W2054395586 date "2014-12-17" @default.
- W2054395586 modified "2023-10-10" @default.
- W2054395586 title "Activation of RidA chaperone function by N-chlorination" @default.
- W2054395586 cites W1241485651 @default.
- W2054395586 cites W1496476288 @default.
- W2054395586 cites W1531324256 @default.
- W2054395586 cites W1555938743 @default.
- W2054395586 cites W1586360287 @default.
- W2054395586 cites W1788190869 @default.
- W2054395586 cites W1915111028 @default.
- W2054395586 cites W1966579230 @default.
- W2054395586 cites W1980734840 @default.
- W2054395586 cites W1987434147 @default.
- W2054395586 cites W1989004365 @default.
- W2054395586 cites W1991299399 @default.
- W2054395586 cites W1992722956 @default.
- W2054395586 cites W1993474323 @default.
- W2054395586 cites W2000860171 @default.
- W2054395586 cites W2011831732 @default.
- W2054395586 cites W2023474993 @default.
- W2054395586 cites W2025464379 @default.
- W2054395586 cites W2025549575 @default.
- W2054395586 cites W2025694904 @default.
- W2054395586 cites W2028390550 @default.
- W2054395586 cites W2029587433 @default.
- W2054395586 cites W2030022020 @default.
- W2054395586 cites W2031421173 @default.
- W2054395586 cites W2032597476 @default.
- W2054395586 cites W2033422497 @default.
- W2054395586 cites W2040447429 @default.
- W2054395586 cites W2049646296 @default.
- W2054395586 cites W2051337736 @default.
- W2054395586 cites W2055848875 @default.
- W2054395586 cites W2068471951 @default.
- W2054395586 cites W2068861782 @default.
- W2054395586 cites W2072284792 @default.
- W2054395586 cites W2074314874 @default.
- W2054395586 cites W2076812698 @default.
- W2054395586 cites W2076846032 @default.
- W2054395586 cites W2078201958 @default.
- W2054395586 cites W2087298783 @default.
- W2054395586 cites W2091400130 @default.
- W2054395586 cites W2097925861 @default.
- W2054395586 cites W2102831230 @default.
- W2054395586 cites W2106342645 @default.
- W2054395586 cites W2111314553 @default.
- W2054395586 cites W2111967267 @default.
- W2054395586 cites W2116137883 @default.
- W2054395586 cites W2117141398 @default.
- W2054395586 cites W2117170204 @default.
- W2054395586 cites W2132684936 @default.
- W2054395586 cites W2133827033 @default.
- W2054395586 cites W2134598541 @default.
- W2054395586 cites W2142527036 @default.
- W2054395586 cites W2148222884 @default.
- W2054395586 cites W2148342439 @default.
- W2054395586 cites W2159410139 @default.
- W2054395586 cites W2169173043 @default.
- W2054395586 cites W2170806980 @default.
- W2054395586 cites W2171030481 @default.
- W2054395586 cites W989016558 @default.
- W2054395586 doi "https://doi.org/10.1038/ncomms6804" @default.
- W2054395586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284807" @default.
- W2054395586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25517874" @default.
- W2054395586 hasPublicationYear "2014" @default.
- W2054395586 type Work @default.
- W2054395586 sameAs 2054395586 @default.
- W2054395586 citedByCount "63" @default.
- W2054395586 countsByYear W20543955862015 @default.
- W2054395586 countsByYear W20543955862016 @default.
- W2054395586 countsByYear W20543955862017 @default.
- W2054395586 countsByYear W20543955862018 @default.
- W2054395586 countsByYear W20543955862019 @default.
- W2054395586 countsByYear W20543955862020 @default.
- W2054395586 countsByYear W20543955862021 @default.
- W2054395586 countsByYear W20543955862022 @default.
- W2054395586 countsByYear W20543955862023 @default.
- W2054395586 crossrefType "journal-article" @default.
- W2054395586 hasAuthorship W2054395586A5003029797 @default.
- W2054395586 hasAuthorship W2054395586A5016264987 @default.
- W2054395586 hasAuthorship W2054395586A5017760059 @default.
- W2054395586 hasAuthorship W2054395586A5031194392 @default.
- W2054395586 hasAuthorship W2054395586A5034841136 @default.
- W2054395586 hasAuthorship W2054395586A5042600518 @default.
- W2054395586 hasBestOaLocation W20543955861 @default.
- W2054395586 hasConcept C104317684 @default.
- W2054395586 hasConcept C142724271 @default.
- W2054395586 hasConcept C181199279 @default.
- W2054395586 hasConcept C185592680 @default.
- W2054395586 hasConcept C2775962898 @default.
- W2054395586 hasConcept C2776151105 @default.
- W2054395586 hasConcept C2779201268 @default.