Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054397809> ?p ?o ?g. }
- W2054397809 endingPage "520" @default.
- W2054397809 startingPage "511" @default.
- W2054397809 abstract "Voluntary exercise increases hippocampal brain-derived neurotrophic factor (BDNF) expression in young animals. In this investigation we examined the induction of BDNF protein in the hippocampus of young (2 months), late middle-aged (15 months) and old (24 months) animals over 4 weeks of exercise. Average running distances decreased with age, with the old animals also maintaining a constant level of activity over time, whereas the other groups tended to increase their average running distance. All animals demonstrated a biphasic profile of BDNF protein induction, with a significant (P<0.05) increase after 1 week of exercise followed by a decrease to near sedentary levels at 2 weeks. After this, BDNF protein levels increased significantly (P<0.05), as compared to baseline, primarily only in the young animals. In whole hippocampal homogenates, only particular BDNF mRNA exons were significantly (P<0.05) changed as a result of exercise, with the largest induction occurring in young animals. BDNF protein induction may, therefore, not be directly correlated with significant mRNA changes. Exercise may represent a therapeutic tool for disorders which involve a decrease in BDNF." @default.
- W2054397809 created "2016-06-24" @default.
- W2054397809 creator A5012093503 @default.
- W2054397809 creator A5023428581 @default.
- W2054397809 creator A5059339971 @default.
- W2054397809 date "2005-04-01" @default.
- W2054397809 modified "2023-09-29" @default.
- W2054397809 title "The exercise-induced expression of BDNF within the hippocampus varies across life-span" @default.
- W2054397809 cites W1555962635 @default.
- W2054397809 cites W1680853665 @default.
- W2054397809 cites W1899025964 @default.
- W2054397809 cites W1967316112 @default.
- W2054397809 cites W1969060329 @default.
- W2054397809 cites W1969858850 @default.
- W2054397809 cites W1970516662 @default.
- W2054397809 cites W1979305117 @default.
- W2054397809 cites W1979794821 @default.
- W2054397809 cites W1979826975 @default.
- W2054397809 cites W1980003647 @default.
- W2054397809 cites W1980145665 @default.
- W2054397809 cites W1983581469 @default.
- W2054397809 cites W1991463397 @default.
- W2054397809 cites W1993247547 @default.
- W2054397809 cites W1994067502 @default.
- W2054397809 cites W1995188451 @default.
- W2054397809 cites W1999871144 @default.
- W2054397809 cites W2005170723 @default.
- W2054397809 cites W2008418293 @default.
- W2054397809 cites W2010204683 @default.
- W2054397809 cites W2011644002 @default.
- W2054397809 cites W2014203854 @default.
- W2054397809 cites W2014470926 @default.
- W2054397809 cites W2017396454 @default.
- W2054397809 cites W2021551531 @default.
- W2054397809 cites W2021958664 @default.
- W2054397809 cites W2025193019 @default.
- W2054397809 cites W2029098677 @default.
- W2054397809 cites W2033333756 @default.
- W2054397809 cites W2034456670 @default.
- W2054397809 cites W2034758657 @default.
- W2054397809 cites W2037916123 @default.
- W2054397809 cites W2040547119 @default.
- W2054397809 cites W2040897211 @default.
- W2054397809 cites W2041285433 @default.
- W2054397809 cites W2042271113 @default.
- W2054397809 cites W2046296359 @default.
- W2054397809 cites W2047663606 @default.
- W2054397809 cites W2047961162 @default.
- W2054397809 cites W2052737201 @default.
- W2054397809 cites W2054698601 @default.
- W2054397809 cites W2055357706 @default.
- W2054397809 cites W2055746351 @default.
- W2054397809 cites W2057144428 @default.
- W2054397809 cites W2060446687 @default.
- W2054397809 cites W2063849763 @default.
- W2054397809 cites W2072249165 @default.
- W2054397809 cites W2079156156 @default.
- W2054397809 cites W2081115340 @default.
- W2054397809 cites W2083194463 @default.
- W2054397809 cites W2086135754 @default.
- W2054397809 cites W2100464372 @default.
- W2054397809 cites W2104792456 @default.
- W2054397809 cites W2112633417 @default.
- W2054397809 cites W2117830068 @default.
- W2054397809 cites W2118726420 @default.
- W2054397809 cites W2121108664 @default.
- W2054397809 cites W2130112708 @default.
- W2054397809 cites W2130417276 @default.
- W2054397809 cites W2146267270 @default.
- W2054397809 cites W2148625946 @default.
- W2054397809 cites W2158506678 @default.
- W2054397809 cites W2161259339 @default.
- W2054397809 cites W2406880264 @default.
- W2054397809 doi "https://doi.org/10.1016/j.neurobiolaging.2004.05.006" @default.
- W2054397809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15653179" @default.
- W2054397809 hasPublicationYear "2005" @default.
- W2054397809 type Work @default.
- W2054397809 sameAs 2054397809 @default.
- W2054397809 citedByCount "232" @default.
- W2054397809 countsByYear W20543978092012 @default.
- W2054397809 countsByYear W20543978092013 @default.
- W2054397809 countsByYear W20543978092014 @default.
- W2054397809 countsByYear W20543978092015 @default.
- W2054397809 countsByYear W20543978092016 @default.
- W2054397809 countsByYear W20543978092017 @default.
- W2054397809 countsByYear W20543978092018 @default.
- W2054397809 countsByYear W20543978092019 @default.
- W2054397809 countsByYear W20543978092020 @default.
- W2054397809 countsByYear W20543978092021 @default.
- W2054397809 countsByYear W20543978092022 @default.
- W2054397809 countsByYear W20543978092023 @default.
- W2054397809 crossrefType "journal-article" @default.
- W2054397809 hasAuthorship W2054397809A5012093503 @default.
- W2054397809 hasAuthorship W2054397809A5023428581 @default.
- W2054397809 hasAuthorship W2054397809A5059339971 @default.
- W2054397809 hasConcept C104317684 @default.
- W2054397809 hasConcept C126322002 @default.
- W2054397809 hasConcept C134018914 @default.