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• W2054402331 startingPage "1448" @default.
• W2054402331 abstract "Abstract The interaction between B7‐H1 (PD‐L1) expressed on APC with PD‐1 expressed by T cells was shown previously to result in inhibition of T‐cell activation and autoimmune diseases. A paper in this issue of the European Journal of Immunology demonstrates that DC B7‐H1 expression can in fact enhance autoimmunity, rather than suppress it. Using a model of direct injection of self antigen‐loaded DC into the CNS, the authors demonstrate that DC with intact B7‐H1 expression exacerbate CNS autoimmune disease. Importantly, the improved disease outcome in animals treated with B7‐H1 −/− DC is a result of a population of CD8 + Treg cells that expand at the site of autoimmune inflammation." @default.
• W2054402331 created "2016-06-24" @default.
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• W2054402331 date "2009-06-01" @default.
• W2054402331 modified "2023-09-30" @default.
• W2054402331 title "B7&hyphen;H1 and CD8^&plus;Treg: The enigmatic role of B7&hyphen;H1 in peripheral tolerance" @default.
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• W2054402331 doi "https://doi.org/10.1002/eji.200939541" @default.
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